Topical ophthalmic atropine in horses, pharmacokinetics and effect on intestinal motility

BMC Veterinary Research

Table 2 Inter-animal variability for the different estimated structural parameters of the disposition model of atropine and individual post-hoc values

Parameters	V_c	Cl	V_t	Cl_d	F Drop (ilogit)	F INF (ilogit)
ETA variance	0.633	0.013	0.213	0.261	7.606	1.123
Shrinkage	0.025	0.253	0.184	0.415	0.364	0.199
IIV (%)	93.95	11.23	48.70	54.60	4483.43	143.98
Individual Post-hoc values
Horse	V_c	Cl	V_t	Cl_d	F Drop	F INF
1	1.862	2.167	1.864	2.312	0.526	0.631
2	1.202	1.780	1.177	2.311	0.517	0.702
3	0.692	1.878	1.892	3.886	0.995	0.651
4	0.200	1.910	0.633	1.422	0.999	0.599
5	1.705	2.248	1.542	2.250	0.731	0.946
6	1.524	1.887	1.580	1.917	0.644	0.977

ETA variance is the estimated variance of the random component of the model and IIV% is the corresponding inter-individual variability calculated from the random components of the model by means of eq. 2. Shrinkage was calculated with eq. 3and value IIV% obtained when shrinkage is > 0.3 should be regarded with caution. Post-hoc individual values were obtained by solving the population model with its fixed and random components. Vc, Vt, Cl, Cld are defined in Table 1. F drop and F infusion are the bioavailability associated to eye drops and infusion administration respectively

ISSN: 1746-6148