Fig. 3

Logarithmic plots of observed atropine plasma concentrations vs. populations predicted (upper plots) and individual predicted atropine plasma concentrations (lower plots) for the single intravenous administration (IV) (left plots), single administration of an ophthalmic solution (eye drops) (middle plots) and 24 h constant rate infusion using a subpalpebral lavage system (SPL) (right plot). All concentrations are given in μg/L. Data were evenly distributed about the line of unity for the IV, eye drops administration and the 24 h SPL-infusion indicating no major bias in neither the population component nor the random component of the model