Fig. 10
From: Topical ophthalmic atropine in horses, pharmacokinetics and effect on intestinal motility
Schematic illustration of the two-compartment model used to characterize atropine concentration-time data. Div, Dtop, Dinf, Vc, Vt, Cl, Cld and ka,denote the dose administered intravenously (bolus), the dose administered topically in the eye either as drop (bolus) or an 24 h infusion (zero-order), the central and peripheral volume of distribution, clearance, inter-compartmental distribution clearance parameter and the absorption rate constant of atropine from the drug deposit in the eye to plasma, respectively