Skip to main content

Table 1 Intra- and interday accuracy and precision (values for liquid chromatography–tandem mass spectrometry (LC-MS/MS) analysis of codeine and its metabolites, norcodeine, codeine-6-glucuronide (C6G), morphine, morphine-6-glucuronide (M3G), and morphine-6-glucuronide (M6G) in equine plasma

From: Functional phenotyping of the CYP2D6 probe drug codeine in the horse

Analyte

Concentration (ng mL− 1)

Intraday accuracy (% nominal concentration)

Intraday precision (% relative SD)

Interday accuracy (% nominal concentration)

Interday precision (% relative SD)

Codeine

0.75

98.0

4.0

104

4.0

40

103

2.0

108

2.0

400

109

0.0

105

1.0

Norcodeine

0.75

95.0

4.0

95.0

3.0

40

95.0

2.0

91.0

1.0

400

110

2.0

105

1.0

C6G

0.75

91.0

4.0

100

3.0

40

100

1.0

94.0

1.0

400

96.0

2.0

102

1.0

Morphine

0.75

109

5.0

108

5.0

40

103

2.0

110

2.0

400

106

2.0

105

2.0

M3G

0.75

92.0

4.0

95.0

4.0

40

109

12.0

107

6.0

400

110

2.0

108

2.0

M6G

0.75

104

5.0

108

7.0

40

107

3.0

108

2.0

400

112

2.0

109

1.0