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Table 1 Intra- and interday accuracy and precision (values for liquid chromatography–tandem mass spectrometry (LC-MS/MS) analysis of codeine and its metabolites, norcodeine, codeine-6-glucuronide (C6G), morphine, morphine-6-glucuronide (M3G), and morphine-6-glucuronide (M6G) in equine plasma

From: Functional phenotyping of the CYP2D6 probe drug codeine in the horse

Analyte Concentration (ng mL− 1) Intraday accuracy (% nominal concentration) Intraday precision (% relative SD) Interday accuracy (% nominal concentration) Interday precision (% relative SD)
Codeine 0.75 98.0 4.0 104 4.0
40 103 2.0 108 2.0
400 109 0.0 105 1.0
Norcodeine 0.75 95.0 4.0 95.0 3.0
40 95.0 2.0 91.0 1.0
400 110 2.0 105 1.0
C6G 0.75 91.0 4.0 100 3.0
40 100 1.0 94.0 1.0
400 96.0 2.0 102 1.0
Morphine 0.75 109 5.0 108 5.0
40 103 2.0 110 2.0
400 106 2.0 105 2.0
M3G 0.75 92.0 4.0 95.0 4.0
40 109 12.0 107 6.0
400 110 2.0 108 2.0
M6G 0.75 104 5.0 108 7.0
40 107 3.0 108 2.0
400 112 2.0 109 1.0