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Table 2 Expression of AQP4 immunohistochemistry in the 12 canine brains following the semiquantitative classification system

From: Aquaporin-4 protein expression in normal canine brains

   N01 N02 N03 N04 N05 N06 N07 N08 N09 N10 N11 N12
Neocortexa GM ++ ++ +/++ -/+ -/+ n/ai -/+ -/+ -/+ -/+ -/+ +/++
WM +++ +++ +++ +++ +++ n/a ++ +++ +++ +++ +++ +++
Basal nucleib GM ++ ++ -/+ -/+ -/+ n/a +/++ +/++ -/+ + + ++
WM ++ ++ ++ ++ +++ n/a ++ ++ ++ ++ ++ ++
Archicortexc GM ++ ++ + n/a +/++ -/+ -/+ +/++ + n/a + ++
WM +++ +++ ++ n/a ++ - - -/+ ++ n/a +++ +++
Paleocortexd   ++ ++ n/a + n/a n/a ++ ++ +/++ +++ ++ +/++
Diencephalone GM ++ ++ -/+ n/a -/+ n/a - - n/a - + +
WM +++ +++ ++ n/a ++ n/a ++ ++ n/a + +++ +++
Midbrain Ponsf GM ++ ++ n/a +/++ + + -/+ - -/+ - - -
WM +++ +++ n/a +++ ++ ++ ++ ++ ++ +/++ ++ +/++
Medulla oblongatag GM ++ ++ n/a +/++ + -/+ - -/+ -/+ - -/+ -
WM +++ +++ n/a +++ +++ ++ ++ ++ +++ +++ ++ ++
Cerebellumh GM ++ ++ n/a ++ +/++ -/+ - -/+ -/+ - - +/++
WM +++ +++ n/a +++ +++ ++ ++ +++ +++ +++ +++ +++
  1. Abbreviations: GM Grey matter, WM White matter, n/a Not applicable; -, negative; +, mild staining; ++, moderate staining; +++, strong staining; Neocortexa: frontal, parietal and temporal areas and subcortical white matter and corpus callosum; Basal nucleib: Striatum body and internal capsule; Archicortexc: hippocampal formation, fimbria and fornix; Paleocortexd: piriform lobe; Diencephalone: epithalamus (habenula nuclei), thalamic nuclei and white matter tracts; Midbrain/ponsf: oculomotor nuclei, red nuclei, substantia nigra, periaqueductal grey matter and white matter tracts (crus cerebri, cerebellar tracts, transverse pontine fibers); Medulla oblongatag: caudal cranial nerves nuclei, white matter tracts (pyramids, medial longitudinal fasciculus, trapezoid body); Cerebellumh: cerebellar cortex and subcortical white matter; n/ai: Not applicable, corresponds to an incomplete evaluation due to the lack of tissue or low immunoreaction