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Fig. 5 | BMC Veterinary Research

Fig. 5

From: Cell engraftment, vascularization, and inflammation after treatment of equine distal limb wounds with endothelial colony forming cells encapsulated within hydrogel microspheres

Fig. 5

(a) Density of von Willebrand factor (vWF) staining (vascularization) normalized to baseline values at weeks 1 and 4 by treatment group in the Inner Wound, Wound Periphery, and Wound Center regions. Data are presented as means and standard deviation. The Wound Center region was only biopsied at week 4. (b) Representative photomicrograph of blood vessel density (brown stain) in the serum treatment group at the Inner Wound region at week 1. (c) Representative photomicrograph of blood vessel density in the ECFC treatment group at the Inner Wound region at week 1. Note the relative increase in blood vessel density in the ECFC treatment group compared to the Serum treatment group in (b) and (c). * indicates a significant difference in vascularization in the Wound Periphery region at week 1, with wounds treated with ECFC having greater blood vessel density compared to wounds treated with MS alone (P = < 0.05). † indicates a significant difference in vascularization in the Wound Periphery region at week 4, with wounds treated with MS alone having greater blood vessel density compared to all other treatment groups (P = < 0.05). Scale bars are 100 μm

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