Table 1 Variations found in the canine BRCA2 gene
From: Mutations of BRCA2 in canine mammary tumors and their targeting potential in clinical therapy
Type of variation | Name/designation | Localization | Studied material | Reference |
|---|---|---|---|---|
1 insertion/deletion | 10204ins/delAAA | NLS2 (exon 27) | Blood samples of tumor-free dogs | [39] |
2 missenses | 10398A > G (Y3397C) 10421A > C (T3405P) | NLS3 (exon 27) | Blood/tissue samples of mammary tumor-bearing and tumor-free dogs | [40] |
4 missenses | H143R, C386W, E643K, K1435R | histone acetyltransferase (HAT), P300/CBP-associated factor (P/CAF), BRC3 | Tissue samples of canine mammary tumor | [41] |
1 insertion | 10,204 insertion AAA | NLS3 | Tissue samples of canine mammary tumor | [41] |
1 silence | 7138C- > T | Fanconi anemia group G protein (FANCG) | Tissue samples of canine mammary tumor | [41] |
1 SNP | ss748770619 | Exon 24 | Blood samples of canine mammary tumors | [21] |
1 SNP | ss748770620 | Exon 27 | Blood samples of canine mammary tumors | [21] |
1 SNP | 2414 G > A | Exon 11 | Tissue samples of canine mammary tumors | [42] |
2 missenses | 2414 A > G 2383 A > C | BRC4 (exon 11) | Tissue samples of canine mammary tumors | [42] |
2 missenses | T1425P K1435R | BRC3 | In silico analysis derived from mammary tumors | [43] |