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Table 1 The MICs (μg/mL) of the selected antibiotics against S. Typhimurium strains before and after exposure to tylosin (taken after 12 and 24 h of incubation) in the in vitro dynamic model and in the presence and absence of an efflux pump inhibitor

From: Tylosin exposure reduces the susceptibility of Salmonella Typhimurium to florfenicol and tetracycline

AntibioticsS. Typhimurium (ATCC-14028)S. Typhimurium (LVPP-STI2)S. Typhimurium (LVPP-STI15)
PrePostPrePostPrePost
WEIEIWEIEIWEIEIWEIEIWEIEIWEIEI
TET22128811128425664512128
MBF0.030.030.060.060.030.030.060.030.50.1320.26
FFL44328423282182
TMP0.040.040.040.040.040.040.160.16>  256>  256>  256>  256
STR32325126410245121024102410241024>  1024>  1024
SMT64646464>  10241024>  1024>  1024>  1024>  1024>  1024>  1024
TYL1024512102451210241024102410241024102410241024
  1. SMX = sulfamethoxazole, TET = tetracycline, FFL = florfenicol, TMP = trimethoprim, MBF = marbofloxacin, STR = streptomycin, and TYL = tylosin, WEI = without the efflux pump inhibitor, EI = together with the efflux pump inhibitor (Phe-Arg-β-naphthylamide, 40 μg/mL). The MIC values were similar for both time points (12 vs 24 h)