Recombinant adenovirus expressing vesicular stomatitis virus G proteins induce both humoral and cell-mediated immune responses in mice and goats

Table 4 Detection of VSV neutralizing antibodies in goats induced by recombinant adenovirus with VSV-NJ at different time points

Group	Mean titers over time after first immunization^a
Group	0 weeks	3 weeks	6 weeks	9 weeks	12 weeks
rAd-IN	0	5 (4–8)	10 (8–16)	10 (8–16)	12 (8–16)
rAd-NJ	0	6 (4–8)	20 (16–20)	47 (32–64)	20 (16–32)
rAd-IN-NJ	0	6 (4–8)	18 (8–18)	47 (32–64)	24 (16–24)
wtAd	0	0	0	0	0
PBS	0	0	0	0	0

^aMean neutralizing antibody titers at that time point (range of antibody titers). VSV-NJ vesicular stomatitis virus-New Jersey; rAd-IN recombinant adenovirus-Indiana; rAd-NJ recombinant adenovirus-New Jersey; rAd-IN-NJ recombinant adenovirus-Indiana-New Jersey; wtAd wild-type adenovirus; PBS, phosphate-buffered saline

ISSN: 1746-6148