Recombinant adenovirus expressing vesicular stomatitis virus G proteins induce both humoral and cell-mediated immune responses in mice and goats

Table 3 Detection of VSV neutralizing antibodies in mice induced by recombinant adenovirus with VSV-NJ at different time points

Group	Mean titers over time after first immunization^a
Group	0 weeks	2 weeks	4 weeks	6 weeks
rAd-IN	0	< 2 (0–2)	6 (4–8)	8 (8)
rAd-NJ	0	< 2 (0–2)	10.4 (8–16)	24 (16–32)
rAd-IN-NJ	0	< 2 (0–2)	12 (8–16)	27.2 (16–32)
wtAd	0	0	6 (4–8)	8 (8)
PBS	0	0	10.4 (8–16)	24 (16–32)

^aMean neutralizing antibody titers at that time point (range of antibody titers). VSV-NJ vesicular stomatitis virus-New Jersey; rAd-IN recombinant adenovirus-Indiana; rAd-NJ recombinant adenovirus-New Jersey; rAd-IN-NJ recombinant adenovirus-Indiana-New Jersey; wtAd wild-type adenovirus; PBS phosphate-buffered saline

ISSN: 1746-6148