Plasma levels of a methadone constant rate infusion and their corresponding effects on thermal and mechanical nociceptive thresholds in dogs

Amon, T.; Kästner, S. B. R.; Kietzmann, M.; Tünsmeyer, J.

doi:10.1186/s12917-020-02735-3

Table 3 Mean ± SD systolic, mean an diastolic arterial pressure (SAP, MAP, DAP) in mmHg and temperature in °C of both groups at different time points

From: Plasma levels of a methadone constant rate infusion and their corresponding effects on thermal and mechanical nociceptive thresholds in dogs

Parameter	Group	BL	0.75 h	1.75 h	3.75 h	7.75 h	11.75 h	23.75 h	27.75 h	31.75 h	35.75 h
SAP (mmHg)	M	140 ± 16	139 ± 7	141 ± 15	146 ± 14	147 ± 13	154 ± 7*	147 ± 13	149 ± 8	150 ± 9	152 ± 10*
SAP (mmHg)	P	142 ± 18	139 ± 12	140 ± 19	140 ± 12	144 ± 15	141 ± 10	137 ± 17	142 ± 10	147 ± 11	140 ± 9
MAP (mmHg)	M	104 ± 9	98 ± 10	104 ± 8	103 ± 12	102 ± 13	108 ± 7	106 ± 12	103 ± 9	104 ± 8	106 ± 11
MAP (mmHg)	P	102 ± 13	102 ± 10	100 ± 9	103 ± 10	104 ± 11	100 ± 5	103 ± 13	86 ± 8	107 ± 7	103 ± 8
DAP (mmHg)	M	85 ± 8	79 ± 11	86 ± 10	81 ± 11	81 ± 15	85 ± 9	86 ± 12	83 ± 12	80 ± 7	86 ± 11
DAP (mmHg)	P	84 ± 11	83 ± 13	80 ± 9	82 ± 5	84 ± 12	83 ± 4	82 ± 8	106 ± 8	85 ± 9	86 ± 7
Temperature (°C)	M	38.4 ± 0.1	37.1 ± 0.4*° p = 0.0002	36.7 ± 0.5*° p < 0.0001	36.7 ± 0.4*° p < 0.0001	36.5 ± 0.4*° p < 0.0001	36.9 ± 0.3*° p < 0.0001	37.0 ± 0.3*° p < 0.0001	36.5 ± 0.4*° p < 0.0001	36.7 ± 0.2*° p < 0.0001	36.9 ± 0.4*° p < 0.0001
Temperature (°C)	P	38.4 ± 0.4	38.1 ± 0.3	38.1 ± 0.3	38.0 ± 0.1*	37.9 ± 0.3*	38.3 ± 0.3	38.6 ± 0.3	37.9 ± 0.1*	38.0 ± 0.3*	38.4 ± 0.3
Parameter	Group	47.75 h	51.75 h	55.75 h	59.75 h	71.75 h	75.75 h	79.75 h	83.75 h	95.75 h
SAP (mmHg)	M	148 ± 13	146 ± 14	149 ± 16	154 ± 13*	146 ± 15	145 ± 16	144 ± 12	143 ± 6	145 ± 8
SAP (mmHg)	P	148 ± 18	141 ± 10	146 ± 11	144 ± 17	142 ± 7	141 ± 13	141 ± 11	145 ± 11	145 ± 18
MAP (mmHg)	M	105 ± 9	101 ± 9	107 ± 8	107 ± 9	102 ± 14	106 ± 10	108 ± 9	110 ± 4	104 ± 5
MAP (mmHg)	P	107 ± 17	105 ± 10	107 ± 6	108 ± 11	105 ± 4	106 ± 13	103 ± 8	109 ± 7	103 ± 13
DAP (mmHg)	M	85 ± 10	80 ± 10	88 ± 8	87 ± 11	82 ± 13	86 ± 7	92 ± 8	89 ± 6	84 ± 6
DAP (mmHg)	P	87 ± 17	90 ± 11	88 ± 5	91 ± 11	86 ± 8	88 ± 13	83 ± 7	93 ± 6	81 ± 12
Temperature (°C)	M	37.3 ± 0.4*° p < 0.0001	36.8 ± 0.5*° p < 0.0001	36.9 ± 0.4*° p < 0.0001	37.2 ± 0.4*° p < 0.0001	37.5 ± 0.6*° p < 0.0001	38.2 ± 0.4	38.6 ± 0.2	39.0 ± 0.3*	38.9 ± 0.2*
Temperature (°C)	P	38.6 ± 0.5	38.2 ± 0.7	38.4 ± 0.6	38.5 ± 0.4	38.7 ± 0.4	38.3 ± 0.5	38.2 ± 0.3	38.4 ± 0.3	38.6 ± 0.4

BL Baseline
*significant difference (p < 0.05) to BL
° significant difference (p < 0.05) between groups, displayed p- values refer to significant differences between groups

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