Skip to main content

Table 3 Mean ± SD systolic, mean an diastolic arterial pressure (SAP, MAP, DAP) in mmHg and temperature in °C of both groups at different time points

From: Plasma levels of a methadone constant rate infusion and their corresponding effects on thermal and mechanical nociceptive thresholds in dogs

Parameter Group BL 0.75 h 1.75 h 3.75 h 7.75 h 11.75 h 23.75 h 27.75 h 31.75 h 35.75 h
SAP (mmHg) M 140 ± 16 139 ± 7 141 ± 15 146 ± 14 147 ± 13 154 ± 7* 147 ± 13 149 ± 8 150 ± 9 152 ± 10*
P 142 ± 18 139 ± 12 140 ± 19 140 ± 12 144 ± 15 141 ± 10 137 ± 17 142 ± 10 147 ± 11 140 ± 9
MAP (mmHg) M 104 ± 9 98 ± 10 104 ± 8 103 ± 12 102 ± 13 108 ± 7 106 ± 12 103 ± 9 104 ± 8 106 ± 11
P 102 ± 13 102 ± 10 100 ± 9 103 ± 10 104 ± 11 100 ± 5 103 ± 13 86 ± 8 107 ± 7 103 ± 8
DAP (mmHg) M 85 ± 8 79 ± 11 86 ± 10 81 ± 11 81 ± 15 85 ± 9 86 ± 12 83 ± 12 80 ± 7 86 ± 11
P 84 ± 11 83 ± 13 80 ± 9 82 ± 5 84 ± 12 83 ± 4 82 ± 8 106 ± 8 85 ± 9 86 ± 7
Temperature (°C) M 38.4 ± 0.1 37.1 ± 0.4*°
p = 0.0002
36.7 ± 0.5*°
p <  0.0001
36.7 ± 0.4*°
p <  0.0001
36.5 ± 0.4*°
p <  0.0001
36.9 ± 0.3*°
p <  0.0001
37.0 ± 0.3*°
p <  0.0001
36.5 ± 0.4*°
p <  0.0001
36.7 ± 0.2*°
p <  0.0001
36.9 ± 0.4*°
p <  0.0001
P 38.4 ± 0.4 38.1 ± 0.3 38.1 ± 0.3 38.0 ± 0.1* 37.9 ± 0.3* 38.3 ± 0.3 38.6 ± 0.3 37.9 ± 0.1* 38.0 ± 0.3* 38.4 ± 0.3
Parameter Group 47.75 h 51.75 h 55.75 h 59.75 h 71.75 h 75.75 h 79.75 h 83.75 h 95.75 h
SAP (mmHg) M 148 ± 13 146 ± 14 149 ± 16 154 ± 13* 146 ± 15 145 ± 16 144 ± 12 143 ± 6 145 ± 8
P 148 ± 18 141 ± 10 146 ± 11 144 ± 17 142 ± 7 141 ± 13 141 ± 11 145 ± 11 145 ± 18
MAP (mmHg) M 105 ± 9 101 ± 9 107 ± 8 107 ± 9 102 ± 14 106 ± 10 108 ± 9 110 ± 4 104 ± 5
P 107 ± 17 105 ± 10 107 ± 6 108 ± 11 105 ± 4 106 ± 13 103 ± 8 109 ± 7 103 ± 13
DAP (mmHg) M 85 ± 10 80 ± 10 88 ± 8 87 ± 11 82 ± 13 86 ± 7 92 ± 8 89 ± 6 84 ± 6
P 87 ± 17 90 ± 11 88 ± 5 91 ± 11 86 ± 8 88 ± 13 83 ± 7 93 ± 6 81 ± 12
Temperature (°C) M 37.3 ± 0.4*°
p <  0.0001
36.8 ± 0.5*°
p <  0.0001
36.9 ± 0.4*°
p <  0.0001
37.2 ± 0.4*°
p <  0.0001
37.5 ± 0.6*°
p <  0.0001
38.2 ± 0.4 38.6 ± 0.2 39.0 ± 0.3* 38.9 ± 0.2*
P 38.6 ± 0.5 38.2 ± 0.7 38.4 ± 0.6 38.5 ± 0.4 38.7 ± 0.4 38.3 ± 0.5 38.2 ± 0.3 38.4 ± 0.3 38.6 ± 0.4
  1. BL Baseline
  2. *significant difference (p < 0.05) to BL
  3. ° significant difference (p < 0.05) between groups, displayed p- values refer to significant differences between groups