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Table 2 Mean ± SD heart rate and respiratory rate in both groups at different time points

From: Plasma levels of a methadone constant rate infusion and their corresponding effects on thermal and mechanical nociceptive thresholds in dogs

Time (h) Heart rate (beats min−1) Respiratory rate (breath min− 1)
Group M Group P Group M Group P
BL 87 ± 12 82 ± 11 16 ± 3 19 ± 4
0.75 66 ± 17* 83 ± 9 12 ± 2* 15 ± 5*
1.75 59 ± 13* 82 ± 14 12 ± 2* 14 ± 3*
2.75 63 ± 13*° (p = 0.0007) 94 ± 8* 13 ± 2* 18 ± 3
3.75 65 ± 11* 89 ± 6 13 ± 2* 14 ± 5*
5.75 61 ± 10* 79 ± 15 13 ± 2* 14 ± 5*
7.75 59 ± 13* 84 ± 7 12 ± 1* 14 ± 4*
9.75 59 ± 10* 82 ± 12 14 ± 2 14 ± 6*
11.75 57 ± 7*° (p = 0.0027) 86 ±10 13 ± 2* 13 ± 3*
23.75 66 ± 18*° (p = 0.0127) 93 ± 7* 14 ± 2 17 ± 3
25.75 55 ± 13*° (p = 0.0002) 88 ± 16 12 ± 0* 13 ± 2*
27.75 61 ± 14* 85 ± 14 15 ± 4 13 ± 2*
29.75 57 ± 12*° (p = 0.0072) 85 ± 16 11 ± 2* 14 ± 3*
31.75 59 ± 12*° (p = 0.0014) 89 ± 10 12 ± 0* 13 ± 3*
33.75 62 ± 14* 85 ± 10 11 ± 1* 12 ± 1*
35.75 60 ± 12*° (p = 0.0011) 90 ± 9 12 ± 0* 15 ± 3*
47.75 65 ± 16*° (p = 0.0182) 91 ± 9 13 ± 2* 16 ± 2
49.75 63 ± 18* 85 ± 10 12 ± 0* 14 ± 2*
51.75 63 ± 13* 83 ± 12 11 ± 1* 15 ± 4*
53.75 62 ± 14*° (p = 0.0260) 88 ± 7 12 ± 2* 13 ± 3*
55.75 55 ± 5*° (p = 0.0182) 82 ± 17 12 ± 0* 13 ± 2*
57.75 63 ± 14* 85 ± 12 12 ± 0* 13 ±2*
59.75 63 ± 11*° (p = 0.0018) 93 ± 8 13 ± 2* 14 ± 2*
71.75 69 ± 16* 87 ± 18 14 ± 3 14 ± 3*
73.75 71 ± 17* 86 ± 14 13 ± 2* 14 ± 2*
75.75 75 ± 28* 87 ± 16 13 ± 2* 13 ± 2*
77.75 80 ± 28 82 ± 18 15 ± 4 12 ± 3*
79.75 95 ± 27 88 ± 12 14 ± 4 13 ± 2*
81.75 90 ± 16 78 ± 15 14 ± 2 13 ± 2*
83.75 103 ± 13* 93 ± 16* 15 ± 3 14 ± 2*
95.75 103 ± 14* 89 ± 9 17 ± 5 17 ± 3
  1. BL Baseline
  2. *significant difference (p < 0.05) to baseline in M
  3. ° significant difference (p < 0.05) between groups, displayed p values refer to significant differences between groups