From: Plasma levels of a methadone constant rate infusion and their corresponding effects on thermal and mechanical nociceptive thresholds in dogs
Mean
SD
Total body clearance (ml kg− 1 min− 1)
51.44
9.47
Mean residence time (h)
3.40
1.74
Volume of distribution at steady state (l kg− 1)
10.26
5.53
Terminal half-life (h)
2.36
1.20