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Table 1 Pharmacokinetic data of methadone CRI in mean ± SD

From: Plasma levels of a methadone constant rate infusion and their corresponding effects on thermal and mechanical nociceptive thresholds in dogs

 

Mean

SD

Total body clearance (ml kg− 1 min− 1)

51.44

9.47

Mean residence time (h)

3.40

1.74

Volume of distribution at steady state (l kg− 1)

10.26

5.53

Terminal half-life (h)

2.36

1.20