# Table 4 Indices of biological variation of fasting insulin concentrations and HOMA-IR in 7 cats (5 lean (BCS = 3/5) and 2 overweight (BCS = 4/5)) sampled once a week for 5 weeks

HOMA-IR
All cats (n = 7)
HOMA-IR
Lean cats (n = 5)
Insulin (mU/L)
All cats (n = 7)
Insulin (mU/L)
Lean cats (n = 5)
Mean 0.78 0.63 3.8 3.2
Range 0.1–2.2 0.1–1.3 0.6–9.8 0.6–6.5
CVG % (95% CI) 52.3 (0-87.7) 51.0 (0-90.1) 54.4 (0-91.2) 52.1 (0-92.1)
CVI % (95% CI) 51.0 (33.4–65.4) 38.2 (22.1–50.2) 48.7 (32.1–62.3) 38.0 (22.1–49.9)
CVA % (95% CI) 7.4 (5.9–9.7) 7.4 (5.8–10.3) 6.6 (5.3–8.6) 6.6 (5.2–9.2)
RCV increase (%) 385 284 364 281
RCV decrease (%) 26 35 27 36
II 1.0 1.31 1.11 1.35
1. CVGindicates between-cat coefficient of variation; CVI within-cat coefficient of variation; CVA analytical coefficient of variation derived from the mixed model analysis; RCV reference change value based on $$RCV \left(\%\right)=100 \text{e}\text{x}\text{p}(\pm 1.96 \sqrt{ 2\left({SD}_{I}^{2}(\text{ln}x\right)+{SD}_{A}^{2}(\text{ln}x\left)\right)}$$ ; II, index of individuality based on CVG/(CVI2 + CVA2)0.5 