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Table 2 Effective concentrations of anthelmintics inhibiting 50% (EC50) and 99% (EC99) of larvae in gastrointestinal nematode (GIN) populations from herds classified as susceptible and resistant, presented as the median, interquartile range (IQR), and range in parenthesis

From: Prevalence of anthelmintic resistance of gastrointestinal nematodes in Polish goat herds assessed by the larval development test

GIN population

No. of herds

EC50

EC99

Benzimidazoles – discriminating concentration (DC) = 0.08 μg/ml

 susceptible

5

0.003, 0.003–0.007 (0.001–0.009)

0.011, 0.008–0.014 (0.001–0.042)

 resistant

37

0.150, 0.050–0.301 (0.014–1.649)

2.990, 0.872–7.371 (0.135–974.682)

Macrocyclic lactones – DC = 21.6 ng/ml

 susceptible

2

0.892 (0.135–1.649)

14.902 (13.398–16.400)

 resistant

40

49.402, 24.533–77.576 (3.669–148.413)

1092.628, 396.322–3122.438 (47.127–257,437.7)

Levamisole – DC = 2.0 μg/ml

 susceptible

37

0.202, 0.135–0.301 (0.025–0.549)

0.724, 0.480–1.148 (0.062–2.185a)

 resistant

5

0.497, 0.449–0.741 (0.301–2.718)

6.446, 3.121–231.343 (2.824–269.110)

  1. a GIN populations from two herds (no. 5 and 23 in Table 1) were classified as susceptible despite ED99 > 2 μg/ml because the corrected percentage larval development at the DC was ≤1%