Prevalence of anthelmintic resistance of gastrointestinal nematodes in Polish goat herds assessed by the larval development test

Mickiewicz, Marcin; Czopowicz, Michał; Moroz, Agata; Potărniche, Adrian-Valentin; Szaluś-Jordanow, Olga; Spinu, Marina; Górski, Paweł; Markowska-Daniel, Iwona; Várady, Marián; Kaba, Jarosław

doi:10.1186/s12917-020-02721-9

Table 1 Results of the larval development test (LDT) in 42 Polish goat herds

From: Prevalence of anthelmintic resistance of gastrointestinal nematodes in Polish goat herds assessed by the larval development test

Herd No.	No. of adult goats	Benzimidazoles					Macrocyclic lactones					Levamisole
Herd No.	No. of adult goats	PD_c (%)	cPD at the DC of 0.08 μg/ml (%) with CI 95%	EC₅₀ (μg/ml)	EC₉₉ (μg/ml)	AR	PD_c (%)	cPD at the DC of 21.6 ng/ml (%) with CI 95%	EC₅₀ (ng/ml)	EC₉₉ (ng/ml)	AR	PD_c (%)	cPD at the DC of 2.0 μg/ml (%) with CI 95%	EC₅₀ (μg/ml)	EC₉₉ (μg/ml)	AR
1	10	98.0	0	0.009	0.011	ND	98.0	70.0 (61.2–77.6)	36.6	546.2	severe	98.0	0	0.41	1.88	ND
2	14	98.0	99.0 (96.4–99.7)	0.273	0.793	severe	97.4	97.7 (94.1–99.1)	134.3	2374	severe	100	9.1 (4.6–17.3)	0.50	3.12	mild
3	16	95.0	42.1 (34.5–50.1)	0.082	1.054	moderate	95.0	41.0 (33.0–49.6)	20.1	924.5	moderate	95.0	0	0.55	2.04	ND
4	26	98.4	77.5 (71.4–82.6)	0.301	5.323	severe	98.4	70.1 (62.3–76.9)	49.4	4891	severe	93.2	0	0.37	1.7	ND
5	5	97.8	31.7 (25.6–38.4)	0.030	2.990	moderate	97.8	59.3 (52.4–65.9)	33.1	1524	severe	97.8	1.0 (0.3–3.6)	0.45	1.13	ND
6	8	98.4	53.9 (46.9–60.6)	0.091	1.354	severe	98.4	100 (98.0–100)	109.9	1094	severe	98.4	3.6 (1.7–7.1)	0.45	2.82	mild
7	4	100	81 (73.7–86.6)	0.165	1.645	severe	100.0	93.3 (87.7–96.4)	148.4	6831	severe	100	0	0.03	0.06	ND
8	35	98.8	97.2 (90.6–99.2)	0.333	0.924	severe	98.8	83.0 (76.2–88.1)	81.5	2169	severe	98.8	0	0.22	0.48	ND
9	40	98.6	2.2 (0.7–7)	0.007	0.042	ND	98.6	53.7 (40.3–66.7)	12.2	560.7	severe	98.6	0	0.27	0.59	ND
10	7	98.7	14.0 (9.5–20.3)	0.014	0.135	moderate	98.7	45.3 (38.4–52.4)	27.1	722.1	moderate	98.7	34.8 (24.3–47.0)	0.74	231.3	moderate
11	23	97.3	91.0 (85.2–94.7)	0.223	0.829	severe	97.3	72.3 (65.1–78.5)	121.5	257,438	severe	97.3	54.4 (40.9–67.3)	2.72	269.1	severe
12	155	98.2	7.3 (3.4–14.9)	0.030	0.300	mild	98.2	85.0 (78.6–89.7)	33.1	329.5	severe	98.2	0	0.30	0.95	ND
13	123	98.6	85.0 (78.4–89.8)	0.223	1.032	severe	98.6	82.8 (76.7–87.5)	99.5	4579	severe	98.6	0	0.45	1.13	ND
14	13	93.2	31.8 (25.1–39.3)	0.050	4.929	moderate	93.2	61.3 (54.1–68.1)	33.1	3278	severe	92.9	0	0.06	0.38	ND
15	11	95.0	84.9 (78.7–89.5)	0.247	1.991	severe	95.0	97.1 (93.5–98.7)	134.3	1725	severe	95	0	0.45	1.89	ND
16	17	86.8	27.9 (20.6–36.5)	0.050	1.065	moderate	86.8	52.4 (43.9–60.8)	24.5	7661	severe	86.8	0	0.22	1.80	ND
17	13	86.8	10.7 (7.1–15.8)	0.018	0.392	moderate	86.8	52.1 (44.9–59.3)	27.1	1248	severe	86.8	0	0.15	1.49	ND
18	10	97.9	56.3 (47.7–64.6)	0.081	3.778	severe	97.9	77.2 (69.7–83.3)	73.7	1577	severe	97.9	0	0.18	0.85	ND
19	20	98.7	0	0.003	0.008	ND	98.7	65.3 (55.0–74.3)	30.0	2966	severe	98.7	0	0.08	0.31	ND
20	5	96.2	92.2 (86.3–95.7)	0.183	0.679	severe	96.2	79.5 (72.3–85.2)	73.7	3392	severe	96.2	4.8 (2.3–9.8)	0.30	6.45	mild
21	21	100	6.3 (3.2–11.9)	0.014	0.290	mild	100	80.9 (72.3–87.3)	66.7	11,000	severe	100	0	0.14	0.63	ND
22	72	92.4	0	0.003	0.014	ND	92.4	20.0 (14.8–26.4)	9.0	240.4	moderate	92.4	0	0.10	0.63	ND
23	11	91.6	15.3 (11.0–20.9)	0.025	0.529	moderate	91.6	37.7 (31.2–44.6)	11.0	1091	moderate	91.6	1.1 (0.3–3.7)	0.09	1.17	ND
24	14	97.0	84.5 (78.9–88.9)	0.607	189.4	severe	97.0	63.9 (57.1–70.3)	54.6	5405	severe	97.0	0	0.18	1.15	ND
25	26	94.0	18.6 (13.8–24.6)	0.022	2.215	moderate	94.0	18.6 (13.8–24.6)	4.5	1400	moderate	94.0	0	0.10	0.37	ND
26	10	94.0	42.6 (35.9–49.5)	0.074	3.419	moderate	94.0	50.5 (43.7–57.4)	24.5	244.1	severe	94.0	0	0.13	0.48	ND
27	8	90.8	22.0 (16.8–28.3)	0.015	4.683	moderate	90.8	0	1.6	16.4	ND	90.8	0	0.09	0.42	ND
28	16	96.8	94.5 (90.5–96.9)	0.905	9.003	severe	96.8	52.2 (45.3–59)	22.2	285.1	severe	96.8	0	0.18	0.58	ND
29	10	93.2	91.2 (86.5–94.4)	0.741	7.371	severe	93.2	92.8 (88.4–95.6)	54.6	252.6	severe	93.2	0	0.25	0.62	ND
30	16	92.2	32.0 (25.9–38.7)	0.041	0.872	moderate	92.2	94.9 (90.9–97.2)	49.4	183.6	severe	92.6	0	0.20	0.51	ND
31	20	94.8	95.5 (91.6–97.6)	0.497	6.378	severe	94.8	96 (92.3–98)	90.0	283.9	severe	94.8	0	0.22	0.70	ND
32	9	98.8	31.8 (24.8–39.8)	0.061	0.605	moderate	98.8	93.4 (87.5–96.7)	73.7	463.1	severe	98.8	0	0.45	1.42	ND
33	76	97.9	0	0.001	0.001	ND	97.9	0	0.1	13.4	ND	97.9	0	0.06	0.38	ND
34	13	98.9	91.4 (86.0–94.8)	0.497	155.1	severe	98.9	67.1 (59.8–73.7)	54.6	5405	severe	98.9	0	0.18	0.74	ND
35	10	97.8	92.6 (86.0–96.2)	0.368	7.873	severe	97.8	96.3 (91–98.5)	73.7	595.1	severe	97.8	0	0.27	0.72	ND
36	27	90.6	81.7 (75.7–86.4)	0.368	9.798	severe	90.6	79.4 (72.4–85)	44.7	956.6	severe	90.6	0	0.20	0.93	ND
37	5	96.8	51.5 (44.4–58.5)	0.082	13.54	severe	96.8	5.3 (2.5–11.0)	3.7	47.1	mild	96.8	0	0.20	0.64	ND
38	6	97.0	90.7 (84.1–94.8)	1.649	974.7	severe	97.0	83.5 (75.6–89.2)	54.6	543.2	severe	97.0	0	0.27	0.86	ND
39	73	97.2	88.0 (81.0–92.6)	0.301	5.232	severe	97.2	92.0 (85.9–95.6)	109.9	2353	severe	97.2	0.9 (0.2–4.5)	0.47	2.19	ND
40	22	88.9	57.9 (50.6–64.9)	0.135	13.40	severe	88.9	7.9 (4.8–12.7)	9.0	56.7	mild	88.9	0	0.17	0.41	ND
41	21	98.8	63.4 (54.8–71.2)	0.165	16.37	severe	98.8	94.9 (90.4–97.4)	121.5	562.1	severe	98.8	0	0.18	0.39	ND
42	18	93.2	63.3 (53.5–72.1)	0.150	3.201	severe	93.2	29.0 (21.0–38.5)	12.2	260.7	moderate	93.2	0	0.33	1.05	ND

AR anthelmintic resistance, DC discriminating concentration, PD_c percentage of developing larvae in the control wells, cPD at the DC corrected percentage of larvae developing in tested wells at the discriminating concentration of a given anthelmintic agent, CI 95 95% confidence interval, EC₅₀ median effective concentration, EC₉₉ the 99th percentile effective concentration, ND not detected

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