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Table 1 Results of the larval development test (LDT) in 42 Polish goat herds

From: Prevalence of anthelmintic resistance of gastrointestinal nematodes in Polish goat herds assessed by the larval development test

Herd No. No. of adult goats Benzimidazoles Macrocyclic lactones Levamisole
PDc (%) cPD at the DC of 0.08 μg/ml (%) with CI 95% EC50 (μg/ml) EC99 (μg/ml) AR PDc (%) cPD at the DC of 21.6 ng/ml (%) with CI 95% EC50 (ng/ml) EC99 (ng/ml) AR PDc (%) cPD at the DC of 2.0 μg/ml (%) with CI 95% EC50 (μg/ml) EC99 (μg/ml) AR
1 10 98.0 0 0.009 0.011 ND 98.0 70.0 (61.2–77.6) 36.6 546.2 severe 98.0 0 0.41 1.88 ND
2 14 98.0 99.0 (96.4–99.7) 0.273 0.793 severe 97.4 97.7 (94.1–99.1) 134.3 2374 severe 100 9.1 (4.6–17.3) 0.50 3.12 mild
3 16 95.0 42.1 (34.5–50.1) 0.082 1.054 moderate 95.0 41.0 (33.0–49.6) 20.1 924.5 moderate 95.0 0 0.55 2.04 ND
4 26 98.4 77.5 (71.4–82.6) 0.301 5.323 severe 98.4 70.1 (62.3–76.9) 49.4 4891 severe 93.2 0 0.37 1.7 ND
5 5 97.8 31.7 (25.6–38.4) 0.030 2.990 moderate 97.8 59.3 (52.4–65.9) 33.1 1524 severe 97.8 1.0 (0.3–3.6) 0.45 1.13 ND
6 8 98.4 53.9 (46.9–60.6) 0.091 1.354 severe 98.4 100 (98.0–100) 109.9 1094 severe 98.4 3.6 (1.7–7.1) 0.45 2.82 mild
7 4 100 81 (73.7–86.6) 0.165 1.645 severe 100.0 93.3 (87.7–96.4) 148.4 6831 severe 100 0 0.03 0.06 ND
8 35 98.8 97.2 (90.6–99.2) 0.333 0.924 severe 98.8 83.0 (76.2–88.1) 81.5 2169 severe 98.8 0 0.22 0.48 ND
9 40 98.6 2.2 (0.7–7) 0.007 0.042 ND 98.6 53.7 (40.3–66.7) 12.2 560.7 severe 98.6 0 0.27 0.59 ND
10 7 98.7 14.0 (9.5–20.3) 0.014 0.135 moderate 98.7 45.3 (38.4–52.4) 27.1 722.1 moderate 98.7 34.8 (24.3–47.0) 0.74 231.3 moderate
11 23 97.3 91.0 (85.2–94.7) 0.223 0.829 severe 97.3 72.3 (65.1–78.5) 121.5 257,438 severe 97.3 54.4 (40.9–67.3) 2.72 269.1 severe
12 155 98.2 7.3 (3.4–14.9) 0.030 0.300 mild 98.2 85.0 (78.6–89.7) 33.1 329.5 severe 98.2 0 0.30 0.95 ND
13 123 98.6 85.0 (78.4–89.8) 0.223 1.032 severe 98.6 82.8 (76.7–87.5) 99.5 4579 severe 98.6 0 0.45 1.13 ND
14 13 93.2 31.8 (25.1–39.3) 0.050 4.929 moderate 93.2 61.3 (54.1–68.1) 33.1 3278 severe 92.9 0 0.06 0.38 ND
15 11 95.0 84.9 (78.7–89.5) 0.247 1.991 severe 95.0 97.1 (93.5–98.7) 134.3 1725 severe 95 0 0.45 1.89 ND
16 17 86.8 27.9 (20.6–36.5) 0.050 1.065 moderate 86.8 52.4 (43.9–60.8) 24.5 7661 severe 86.8 0 0.22 1.80 ND
17 13 86.8 10.7 (7.1–15.8) 0.018 0.392 moderate 86.8 52.1 (44.9–59.3) 27.1 1248 severe 86.8 0 0.15 1.49 ND
18 10 97.9 56.3 (47.7–64.6) 0.081 3.778 severe 97.9 77.2 (69.7–83.3) 73.7 1577 severe 97.9 0 0.18 0.85 ND
19 20 98.7 0 0.003 0.008 ND 98.7 65.3 (55.0–74.3) 30.0 2966 severe 98.7 0 0.08 0.31 ND
20 5 96.2 92.2 (86.3–95.7) 0.183 0.679 severe 96.2 79.5 (72.3–85.2) 73.7 3392 severe 96.2 4.8 (2.3–9.8) 0.30 6.45 mild
21 21 100 6.3 (3.2–11.9) 0.014 0.290 mild 100 80.9 (72.3–87.3) 66.7 11,000 severe 100 0 0.14 0.63 ND
22 72 92.4 0 0.003 0.014 ND 92.4 20.0 (14.8–26.4) 9.0 240.4 moderate 92.4 0 0.10 0.63 ND
23 11 91.6 15.3 (11.0–20.9) 0.025 0.529 moderate 91.6 37.7 (31.2–44.6) 11.0 1091 moderate 91.6 1.1 (0.3–3.7) 0.09 1.17 ND
24 14 97.0 84.5 (78.9–88.9) 0.607 189.4 severe 97.0 63.9 (57.1–70.3) 54.6 5405 severe 97.0 0 0.18 1.15 ND
25 26 94.0 18.6 (13.8–24.6) 0.022 2.215 moderate 94.0 18.6 (13.8–24.6) 4.5 1400 moderate 94.0 0 0.10 0.37 ND
26 10 94.0 42.6 (35.9–49.5) 0.074 3.419 moderate 94.0 50.5 (43.7–57.4) 24.5 244.1 severe 94.0 0 0.13 0.48 ND
27 8 90.8 22.0 (16.8–28.3) 0.015 4.683 moderate 90.8 0 1.6 16.4 ND 90.8 0 0.09 0.42 ND
28 16 96.8 94.5 (90.5–96.9) 0.905 9.003 severe 96.8 52.2 (45.3–59) 22.2 285.1 severe 96.8 0 0.18 0.58 ND
29 10 93.2 91.2 (86.5–94.4) 0.741 7.371 severe 93.2 92.8 (88.4–95.6) 54.6 252.6 severe 93.2 0 0.25 0.62 ND
30 16 92.2 32.0 (25.9–38.7) 0.041 0.872 moderate 92.2 94.9 (90.9–97.2) 49.4 183.6 severe 92.6 0 0.20 0.51 ND
31 20 94.8 95.5 (91.6–97.6) 0.497 6.378 severe 94.8 96 (92.3–98) 90.0 283.9 severe 94.8 0 0.22 0.70 ND
32 9 98.8 31.8 (24.8–39.8) 0.061 0.605 moderate 98.8 93.4 (87.5–96.7) 73.7 463.1 severe 98.8 0 0.45 1.42 ND
33 76 97.9 0 0.001 0.001 ND 97.9 0 0.1 13.4 ND 97.9 0 0.06 0.38 ND
34 13 98.9 91.4 (86.0–94.8) 0.497 155.1 severe 98.9 67.1 (59.8–73.7) 54.6 5405 severe 98.9 0 0.18 0.74 ND
35 10 97.8 92.6 (86.0–96.2) 0.368 7.873 severe 97.8 96.3 (91–98.5) 73.7 595.1 severe 97.8 0 0.27 0.72 ND
36 27 90.6 81.7 (75.7–86.4) 0.368 9.798 severe 90.6 79.4 (72.4–85) 44.7 956.6 severe 90.6 0 0.20 0.93 ND
37 5 96.8 51.5 (44.4–58.5) 0.082 13.54 severe 96.8 5.3 (2.5–11.0) 3.7 47.1 mild 96.8 0 0.20 0.64 ND
38 6 97.0 90.7 (84.1–94.8) 1.649 974.7 severe 97.0 83.5 (75.6–89.2) 54.6 543.2 severe 97.0 0 0.27 0.86 ND
39 73 97.2 88.0 (81.0–92.6) 0.301 5.232 severe 97.2 92.0 (85.9–95.6) 109.9 2353 severe 97.2 0.9 (0.2–4.5) 0.47 2.19 ND
40 22 88.9 57.9 (50.6–64.9) 0.135 13.40 severe 88.9 7.9 (4.8–12.7) 9.0 56.7 mild 88.9 0 0.17 0.41 ND
41 21 98.8 63.4 (54.8–71.2) 0.165 16.37 severe 98.8 94.9 (90.4–97.4) 121.5 562.1 severe 98.8 0 0.18 0.39 ND
42 18 93.2 63.3 (53.5–72.1) 0.150 3.201 severe 93.2 29.0 (21.0–38.5) 12.2 260.7 moderate 93.2 0 0.33 1.05 ND
  1. AR anthelmintic resistance, DC discriminating concentration, PDc percentage of developing larvae in the control wells, cPD at the DC corrected percentage of larvae developing in tested wells at the discriminating concentration of a given anthelmintic agent, CI 95 95% confidence interval, EC50 median effective concentration, EC99 the 99th percentile effective concentration, ND not detected
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