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Table 4 iPSCs for Disease Research

From: The use of induced pluripotent stem cells in domestic animals: a narrative review

Disease Target Origin Cell Type Differentiated Cell Type Route of Administration Outcome Reference
Porcine
 Osteoporosis Fibroblasts Osteoblast-like cells Local cell transplantation Significant improvement in bone structures at transplanted site; maintenance of bone structures locally [141]
 Osteochondral damage, osteoarthritis Adult fibroblasts piPSC-like cells Direct pellet transplantation Cartilage regeneration; no tumor formation [24]
 Chronic myocardial infarction Adult fibroblasts piPSCs Direct injection Integration of iPSCs into cardiac muscle without differentiation; potential contribution to angiogenesis [51]
 Acute myocardial infarction Adult fibroblasts piPSCs Direct injection Significant decrease in infarcted area; improvement in local function and perfusion [142]
 Myocardial infraction Adult MSCs Endothelial cells (ECs) Local injections Improved function and an increase in the number of capillaries in the peri-infarct area; no significant changes in infarct area size. [77]
 Chronic spinal cord injury Adult fibroblasts Neural precursor cells (NPCs) Bilateral syngeneic grafts Long-term immune tolerance of NPCs; integration into and beyond grafted region [54]
 Retinal damage Fetal fibroblasts Rod photoreceptors Local injection Integration into damaged porcine neural retina [78, 143]
Equine
 Muscle injury Adult MSCs eiPSCs Intramuscular injection Partial muscle regeneration; in vivo differentiation of eiPSCs into myofibers at the injury site [87]
 Musculoskeletal injury Adult MSCs MSCs Injection into lesion Improvements in clinical conditions for injuries including fractures, tendonitis, osteochondrosis, and osteoarthritis [144]
Canine
 Hind limb ischemia Adult MSCs and fibroblasts Endothelial cells Local injections Successful engraftment in the ischemic limb; significant improvement of vascularization locally [92]
 Cardiac infarction Adult MSCs and fibroblasts Endothelial cells Local injections Successful engraftment locally; improvement in cardiac contractility [92]