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Table 3 iPSC publications relating to tissue and disease modelling

From: The use of induced pluripotent stem cells in domestic animals: a narrative review

Origin cell type Differentiated cell type Tissue or disease target Outcome Reference
Porcine
 Fibroblasts Neural Rosettes, neural crest-like cells, and peripheral sensory neural-like cells Neural tissue Indications of neural differentiation by the upregulation of sensory neuron genes and peripheral neuron markers [121]
 Adult fibroblasts Neurons, astrocytes, and oligodendrocytes Neural tissue Indications of neural differentiation by the presence of mature neural markers and morphology of neurons, astrocytes, and oligodendrocytes; indications of further differentiation into motor neurons. [76]
 Fetal fibroblasts Neural progenitor cells Neural tissue Production of neural progenitor cells with expression of neuronal markers [41]
 Fetal fibroblasts Endothelial cells Endothelial tissue Production of endothelial cells with morphological and functional properties [30]
 Fetal fibroblasts Hepatocyte-like cells Liver tissue Production of differentiated cells characteristic of hepatocytes by functional properties [78]
 Adult fibroblasts Hepatocyte-like cells Liver tissue Production of differentiated cells characteristic of hepatocytes functional properties [50]
 Fetal fibroblasts Vascular smooth muscle cells Muscle tissue Production of vascular smooth muscle cells capable of forming 3D scaffold-free tissue rings [42]
Equine
 Adult fibroblasts Cortical neurons West Nile Virus (WNV) and Murray Valley Encephalitis (MVEV) Successful infection of functional eiPSC-derived neurons by WNV and MVEV [127]
 Adult keratinocytes Cholinergic motor neurons Motor Neurons Production of functional neurons capable of generating action potentials [86]
 Fetal and adult fibroblasts Tenocytes Tendons Formation of three-dimensional artificial tendons [128]
 Fetal fibroblasts Skeletal myotubes Muscle Tissue Formation of eiPSC-derived muscle fibers with electrophysiological function [122]
 Adult fibroblasts Osteoblasts Bone Formation of eiPSC-derived bone tissue capable of secreting hydroxyapatite and calcium matrix [129]
 Adult keratinocytes Primary keratinocytes Epidermal wounds Creation of artificial tissues for potential skin graft applications [84]
Canine
 Adult fibroblasts MSCs Cartilage and Bone Tissue Formation of three-dimensional chondrogenic and osteogenic cultures [130]
 Fetal fibroblasts Mature megakaryocytes Thrombocytopenia Production of cells capable of releasing functional platelets upon signaling induction [131]
Bovine
 Adult testicular cells N/A Phthalate ester exposure Significant reduction in androgen expression and increase in apoptosis [94]
 Adult epithelial cells Mammary epithelial-like cells Mammary tissue Indication of mammary phenotype for iPSCs cultured with progesterone [97]
Galline
 Fetal fibroblasts N/A Goose influenza H5 Incorporation of replication-incompetent virus into iPSCs [100]
 Fetal fibroblasts N/A Newcastle disease virus (NDV) Successful infection of iPSCs with NDV; viable iPSCs exhibited increased tolerability [132, 133]