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Fig. 3 | BMC Veterinary Research

Fig. 3

From: The use of induced pluripotent stem cells in domestic animals: a narrative review

Fig. 3

Potential Use of Domestic Animal iPSCs for Drug Discovery, Disease Modelling and Cell Replacement Therapy. Induced pluripotent stem cell (iPSCs) can be generated from healthy animals (e.g. dogs) for allogeneic cell transplantation of therapeutic cell types/tissue indicative of the disease. Alternatively, iPSCs can be generated from animals harbouring a genetic disorder and through CRISPR/Cas9-mediated genome editing technologies these genetic mutations can be corrected so that differentiated cell products from these iPSCs can be utilized in autologous cell replacement therapies. In addition, both the genetically mutated iPSCs and their genome-corrected iPSCs can be compared and contrasted for disease modelling purposes. This disease-in-a-dish could be potentially use as a high throughput screening system to discover novel drug candidates. Figure by Dean H. Betts (Adobe Photoshop)

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