Fig. 2

Induced Pluripotent Stem Cell Production and Differentiation. Differentiated cells, e.g. adult fibroblast cells [1], can be reprogrammed via designated reprogramming factors (e.g. Oct4, Sox2, Klf4, and c-Myc), to create iPSCs [2]. Upon exposure to specific differentiation media, iPSCs are capable of differentiating into any cell type of the body, e.g. multipotent neural cells [3]. Under appropriate culture conditions, iPSCs can result in a fully differentiated cell, e.g. a motor neuron [4]. Figure from “Induced pluripotent stem cell model of lysosomal storage disorders,” by Borger DK et al., 2017, Dis Model Mech. 10:691–704, CCBY [28] with minor alterations using Microsoft Word