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Fig. 12 | BMC Veterinary Research

Fig. 12

From: Deep pemphigus (pemphigus vulgaris, pemphigus vegetans and paraneoplastic pemphigus) in dogs, cats and horses: a comprehensive review

Fig. 12

Histological characteristics of canine paraneoplastic pemphigus. a: an acantholytic suprabasal cleft in the epidermis retains a single row of basal keratinocytes (arrow) at its base, similar to pemphigus vulgaris. These basal cells are variably rounded or flattened - variation that is attributable to additional basal cell injury from concurrent interface dermatitis. Mild lymphocytic exocytosis occurs in the epidermis and the dermis has mixed neutrophilic and lymphocytic dermatitis; b and c: a lymphocytic cytotoxic dermatitis targets the basal layer (interface dermatitis) and suprabasal layers of the epidermis (b) and hair follicle infundibulum (c), which is similar to erythema multiforme. Apoptotic keratinocytes (arrows) are at different epithelial levels and are associated with lymphocytic exocytosis. b and c are from the same dog as (a) but are from different skin areas. a and b – 40x magnification. c – 20x magnification. Hematoxylin and eosin. All pictures are courtesy of Keith E. Linder

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