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Table 5 AUC, sensitivity and specificity of potential biomarkers for LDA identification

From: Potential hemo-biological identification markers to the left displaced abomasum in dairy cows

  Energy metabolism biomarkers Liver/kidney function biomarkers Minerals
NEFA BHBA INS GC RQUICKI ALT AST GGT LDH TBIL DBIL IBIL TP ALB BUN Creatinine Cl Ca K
AUC 0.84 0.75 0.89 0.73 0.89 0.89 0.84 0.88 0.71 0.75 0.74 0.73 0.73 0.82 0.7 0.86 0.81 0.94 0.78
Se 0.77 0.8 0.87 0.73 0.83 0.87 0.7 0.87 0.77 0.73 0.73 0.67 0.43 0.87 0.87 0.97 0.63 0.90 0.70
Sp 0.9 0.65 0.85 0.65 0.85 0.85 0.95 0.75 0.6 0.8 0.75 0.85 0.95 0.7 0.5 0.7 0.95 0.95 0.75
Cp 0.68
mM
0.75
mM
10.4
mU/L
58.6
ng/L
0.68 19.5
U/L
106
U/L
24.5
U/L
812
U/L
4.85
μM
1.65
μM
2.95
μM
67.6
μM
33.0
μM
5.34
mM
74
mM
98
mM
2.25
mM
4.05
mM
  1. Each evaluated variable of the potential biomarkers, including area under the curves (AUCs), sensitivity, specificity, or cut-point, was calculated and shown in the table. Youden Index (YI)was calculated as YI = Sensitivity- (1-specificity). A cut-point for each parameter was chosen when a maximum YI was detected
  2. Se Sensitivity, Sp Specificity, Cp Cut point, NEFA Non-esterified fatty acid, BHBA β-hydroxybutyric acid, INS Insulin, GC Glycagon, RQUICKI Revised quantitative insulin sensitivity check index, ALT Alanine aminotransferase, AST Aspartate aminotransferase, GGT γ glutamyl transpeptidase, LDH Lactate dehydrogenase, TBIL Total bilirubin, DBIL Direct bilirubin, IBIL Indirect bilirubin, TP Total protein, ALB Albumin, BUN Blood urea nitrogen