Potential hemo-biological identification markers to the left displaced abomasum in dairy cows

BMC Veterinary Research

Table 5 AUC, sensitivity and specificity of potential biomarkers for LDA identification

	Energy metabolism biomarkers					Liver/kidney function biomarkers											Minerals
	NEFA	BHBA	INS	GC	RQUICKI	ALT	AST	GGT	LDH	TBIL	DBIL	IBIL	TP	ALB	BUN	Creatinine	Cl	Ca	K
AUC	0.84	0.75	0.89	0.73	0.89	0.89	0.84	0.88	0.71	0.75	0.74	0.73	0.73	0.82	0.7	0.86	0.81	0.94	0.78
Se	0.77	0.8	0.87	0.73	0.83	0.87	0.7	0.87	0.77	0.73	0.73	0.67	0.43	0.87	0.87	0.97	0.63	0.90	0.70
Sp	0.9	0.65	0.85	0.65	0.85	0.85	0.95	0.75	0.6	0.8	0.75	0.85	0.95	0.7	0.5	0.7	0.95	0.95	0.75
Cp	0.68 mM	0.75 mM	10.4 mU/L	58.6 ng/L	0.68	19.5 U/L	106 U/L	24.5 U/L	812 U/L	4.85 μM	1.65 μM	2.95 μM	67.6 μM	33.0 μM	5.34 mM	74 mM	98 mM	2.25 mM	4.05 mM

Each evaluated variable of the potential biomarkers, including area under the curves (AUCs), sensitivity, specificity, or cut-point, was calculated and shown in the table. Youden Index (YI)was calculated as YI = Sensitivity- (1-specificity). A cut-point for each parameter was chosen when a maximum YI was detected
Se Sensitivity, Sp Specificity, Cp Cut point, NEFA Non-esterified fatty acid, BHBA β-hydroxybutyric acid, INS Insulin, GC Glycagon, RQUICKI Revised quantitative insulin sensitivity check index, ALT Alanine aminotransferase, AST Aspartate aminotransferase, GGT γ glutamyl transpeptidase, LDH Lactate dehydrogenase, TBIL Total bilirubin, DBIL Direct bilirubin, IBIL Indirect bilirubin, TP Total protein, ALB Albumin, BUN Blood urea nitrogen

ISSN: 1746-6148