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Table 4 Urinalysis of dogs on day 0, 45, 90 and 118

From: Beagle dog 90-day oral toxicity study of a novel coccidiostat – ethanamizuril

  male female
  SG pH URO SG pH URO
Day 0
 High (n = 6) 1.08 ± 0.03 7.60 ± 0.32 3.11 ± 0.13 1.04 ± 0.04 7.44 ± 0.51 3.15 ± 0.08
 Middle (n = 4) 1.09 ± 0.08 7.74 ± 0.56 3.07 ± 0.08 1.09 ± 0.15 7.39 ± 0.31 3.10 ± 0.09
 Low(n = 4) 1.11 ± 0.04 7.49 ± 0.45 3.09 ± 0.06 1.09 ± 0.04 7.33 ± 0. 42 3.17 ± 0. 06
 Control(n = 6) 1.05 ± 0.02 7.29 ± 0.27 3.09 ± 0.07 1.13 ± 0.08 7.49 ± 0.27 3.17 ± 0.06
Day 45
 High (n = 6) 1.07 ± 0.05 7.32 ± 0.33 3.11 ± 0.13 1.11 ± 0.11 7.41 ± 0.53 3.15 ± 0.08
 Middle (n = 4) 1.09 ± 0.05 7.30 ± 0.14 3.10 ± 0.07 1.03 ± 0.10 7.42 ± 0.34 3.12 ± 0.03
 Low(n = 4) 1.00 ± 0.03 7.47 ± 0.38 3.13 ± 0.09 1.06 ± 0.10 7.34 ± 0. 17 3.19 ± 0. 03
 Control(n = 6) 1.05 ± 0.06 7.31 ± 0.25 3.08 ± 0.10 1.15 ± 0.08 7.37 ± 0.28 3.17 ± 0.10
Day 90
 High (n = 6) 1.09 ± 0.05 7.46 ± 0.42 3.13 ± 0.12 1.06 ± 0.03 7.26 ± 0.53 3.13 ± 0.07
 Middle (n = 4) 1.13 ± 0.10 7.19 ± 0.12 3.05 ± 0.13 1.08 ± 0.06 7.31 ± 0.33 3.11 ± 0.09
 Low(n = 4) 1.04 ± 0.07 7.55 ± 0.35 3.15 ± 0.01 1.10 ± 0.07 7.58 ± 0.36 3.16 ± 0. 04
 Control(n = 6) 1.08 ± 0.07 7.39 ± 0.12 3.12 ± 0.10 1.18 ± 0.04 7.35 ± 0.25 3.13 ± 0.02
Day 118
 High (n = 2) 1.10 ± 0 7.48 ± 0.12 3.08 ± 0.06 1.03 ± 0.06 7.29 ± 0.80 3.17 ± 0.04
 Control(n = 2) 1.08 ± 0.07 7.35 ± 0.30 3.08 ± 0.06 1.09 ± 0.01 7.74 ± 0.01 3.15 ± 0.02
  1. Note: Control, Low, Middle and High refer to 0, 12, 60 and 300 mg/kg ethanamizuril dose. There were no statistically significant differences when the control and test article-treated groups were compared