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Table 3 Clinical chemistry of dogs on day 0, 45, 90 and 118

From: Beagle dog 90-day oral toxicity study of a novel coccidiostat – ethanamizuril

 

Day 0

Day 45

day 90

day 118

 

High (n = 6)

Middle (n = 4)

Low(n = 4)

Control (n = 6)

High (n = 6)

Middle (n = 4)

Low (n = 4)

Control (n = 6)

High (n = 6)

Middle (n = 4)

Low (n = 4)

Control (n = 6)

High (n = 2)

Control (n = 2)

Male

 Alb

(mmol/L)

35.36 ± 2.16

35.42 ± 1.68

36.21 ± 3.89

36.07 ± 2.18

34.87 ± 1.75

36.49 ± 3.70

36.17 ± 3.82

36.67 ± 2.27

35.25 ± 1.65

35.75 ± 2.40

36.03 ± 1.98

36.20 ± 1.89

34.99 ± 1.24

35.71 ± 2.43

 ALT

(U/L)

53.72 ± 6.47

56.87 ± 6.92

53.81 ± 5.10

57.92 ± 6.33

55.25 ± 6.62

54.40 ± 1.76

52.36 ± 2.56

57.66 ± 5.50

54.74 ± 5.93

51.90 ± 3.83

54.88 ± 6.36

55.44 ± 5.21

54.03 ± 7.75

58.77 ± 8.10

 AST

(U/L)

219.07 ± 26.45

206.39 ± 36.90

253.82 ± 31.42

248.25 ± 37.59

226.79 ± 27.84

218.28 ± 12.53

255.55 ± 28.06

233.24 ± 32.73

220.40 ± 30.74

235.21 ± 49.83

235.09 ± 30.69

225.90 ± 37.02

275.27 ± 34.93

226.48 ± 58.58

 BUN

(mmol/L)

5.06 ± 1.21

5.25 ± 1.39

4.85 ± 0.51

4.22 ± 0.88

5.25 ± 1.19

5.16 ± 1.09

5.33 ± 0.67

4.56 ± 0.74

5.63 ± 0.61

4.52 ± 0.94

5.07 ± 0.53

5.08 ± 0.71

4.22 ± 1.85

4.87 ± 1.13

 TCH

(mmol/L)

1.41 ± 0.25

1.58 ± 0.33

1.54 ± 0.28

1.59 ± 0.23

1.37 ± 0.29

1.35 ± 0.28

1.44 ± 0.26

1.61 ± 0.25

1.31 ± 0.35

1.64 ± 0.17

1.49 ± 0.23

1.64 ± 0.11

1.44 ± 0.60

1.65 ± 0.20

 Cr

(umoL/L)

42.93 ± 3.31

40.01 ± 9.07

47.35 ± 2.92

45.48 ± 2.92

45.00 ± 2.29

39.76 ± 4.47

47.33 ± 2.92

45.60 ± 2.50

44.70 ± 2.61

42.92 ± 8.47

45.02 ± 6.74

46.32 ± 4.36

42.67 ± 0.70

45.72 ± 4.54

 Glu

(mmol/L)

4.50 ± 0.91

4.27 ± 1.07

5.61 ± 1.01

5.22 ± 0.86

4.29 ± 1.20

4.46 ± 1.26

5.56 ± 1.03

5.12 ± 0.59

4.17 ± 1.00

4.78 ± 0.61

4.89 ± 0.50

4.91 ± 0.53

5.55 ± 0.21

5.05 ± 0.46

 TP

(G/L)

75.05 ± 2.72

76.01 ± 1.66

75.02 ± 4.60

72.64 ± 3.10

75.07 ± 1.28

75.70 ± 3.35

74.99 ± 4.52

73.35 ± 2.66

74.70 ± 0.74

74.99 ± 2.84

76.01 ± 3.14

75.24 ± 3.29

75.09 ± 1.49

72.49 ± 0.60

 TG

(mmol/L)

1.42 ± 0.06

1.40 ± 0.04

1.43 ± 0.03

1.39 ± 0.06

1.43 ± 0.06

1.42 ± 0.10

1.42 ± 0.05

1.38 ± 0.05

1.46 ± 0.10

1.43 ± 0.08

1.43 ± 0.09

1.39 ± 0.06

1.46 ± 0.02

1.40 ± 0.04

Female

 Alb

(mmol/L)

35.30 ± 2.17

35.39 ± 2.16

36.36 ± 1.83

35.41 ± 2.12

35.36 ± 2.11

36.92 ± 1.52

36.10 ± 2.06

34.85 ± 2.06

34.62 ± 2.38

36.85 ± 2.33

35.59 ± 1.07

36.07 ± 1.23

36.40 ± 4.95

35.71 ± 2.30

 ALT

(U/L)

52.75 ± 6.31

52.31 ± 8.50

59.00 ± 10.26

57.66 ± 7.79

56.12 ± 7.66

51.37 ± 3.48

59.02 ± 10.33

60.49 ± 5.77

53.08 ± 7.40

56.82 ± 8.20

57.08 ± 6.03

56.16 ± 6.25

42.91 ± 0.14

58.76 ± 8.17

 AST

(U/L)

224.24 ± 30.90

225.92 ± 38.31

286.14 ± 39.24

239.81 ± 38.82

212.03 ± 14.14

247.89 ± 35.59

239.62 ± 5.35

240.87 ± 32.28

214.61 ± 19.90

226.69 ± 36.42

230.00 ± 33.50

242.82 ± 30.21

247.70 ± 46.71

226.45 ± 48.51

 BUN

(mmol/L)

5.35 ± 1.14

5.06 ± 1.16

4.71 ± 0.16

4.65 ± 0.66

5.11 ± 1.18

4.85 ± 0.81

3.68 ± 1.51

4.18 ± 0.87

5.27 ± 0.90

4.81 ± 0.49

4.35 ± 0.60

4.90 ± 0.58

5.67 ± 0.58

4.85 ± 1.09

 TCH

(mmol/L)

1.56 ± 0.50

1.49 ± 0.36

1.52 ± 0.46

1.64 ± 0.28

1.42 ± 0.43

1.43 ± 0.24

1.48 ± 0.54

1.60 ± 0.28

1.35 ± 0.16

1.44 ± 0.27

1.58 ± 0.15

1.66 ± 0.23

1.40 ± 0.24

1.65 ± 0.12

 Cr

(umoL/L)

44.75 ± 2.73

46.15 ± 3.65

44.45 ± 3.59

44.17 ± 4.06

43.90 ± 2.06

46.51 ± 4.38

44.38 ± 3.59

45.14 ± 3.15

42.57 ± 3.34

43.85 ± 5.03

46.65 ± 1.93

45.38 ± 2.46

40.09 ± 2.18

45.76 ± 4.44

 Glu

(mmol/L)

4.40 ± 1.16

4.29 ± 1.20

5.97 ± 0.42

5.37 ± 0.84

4.56 ± 0.63

5.00 ± 1.58

5.94 ± 0.51

5.16 ± 0.86

4.31 ± 1.12

4.93 ± 0.89

5.28 ± 0.70

4.74 ± 0.46

4.70 ± 2.13

5.03 ± 0.48

 TP

(G/L)

76.22 ± 3.76

75.17 ± 1.60

73.14 ± 3.68

74.29 ± 3.56

75.77 ± 2.03

76.31 ± 2.58

73.07 ± 3.61

73.35 ± 2.81

75.46 ± 1.26

74.11 ± 3.32

72.87 ± 2.04

71.97 ± 2.37

74.89 ± 0.98

72.46 ± 0.51

 TG

(mmol/L)

1.44 ± 0.09

1.43 ± 0.06

1.48 ± 0.01

1.40 ± 0.07

1.40 ± 0.14

1.36 ± 0.01

1.46 ± 0.05

1.42 ± 0.07

1.40 ± 0.03

1.36 ± 0.13

1.39 ± 0.05

1.34 ± 0.04

1.40 ± 0.04

1.41 ± 0.08

  1. Note: Control, Low, Middle and High refer to 0, 12, 60 and 300 mg/kg ethanamizuril dose. There were no statistically significant differences when the control and test article-treated groups were compared