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Table 3 Clinical chemistry of dogs on day 0, 45, 90 and 118

From: Beagle dog 90-day oral toxicity study of a novel coccidiostat – ethanamizuril

  Day 0 Day 45 day 90 day 118
  High (n = 6) Middle (n = 4) Low(n = 4) Control (n = 6) High (n = 6) Middle (n = 4) Low (n = 4) Control (n = 6) High (n = 6) Middle (n = 4) Low (n = 4) Control (n = 6) High (n = 2) Control (n = 2)
Male
 Alb
(mmol/L)
35.36 ± 2.16 35.42 ± 1.68 36.21 ± 3.89 36.07 ± 2.18 34.87 ± 1.75 36.49 ± 3.70 36.17 ± 3.82 36.67 ± 2.27 35.25 ± 1.65 35.75 ± 2.40 36.03 ± 1.98 36.20 ± 1.89 34.99 ± 1.24 35.71 ± 2.43
 ALT
(U/L)
53.72 ± 6.47 56.87 ± 6.92 53.81 ± 5.10 57.92 ± 6.33 55.25 ± 6.62 54.40 ± 1.76 52.36 ± 2.56 57.66 ± 5.50 54.74 ± 5.93 51.90 ± 3.83 54.88 ± 6.36 55.44 ± 5.21 54.03 ± 7.75 58.77 ± 8.10
 AST
(U/L)
219.07 ± 26.45 206.39 ± 36.90 253.82 ± 31.42 248.25 ± 37.59 226.79 ± 27.84 218.28 ± 12.53 255.55 ± 28.06 233.24 ± 32.73 220.40 ± 30.74 235.21 ± 49.83 235.09 ± 30.69 225.90 ± 37.02 275.27 ± 34.93 226.48 ± 58.58
 BUN
(mmol/L)
5.06 ± 1.21 5.25 ± 1.39 4.85 ± 0.51 4.22 ± 0.88 5.25 ± 1.19 5.16 ± 1.09 5.33 ± 0.67 4.56 ± 0.74 5.63 ± 0.61 4.52 ± 0.94 5.07 ± 0.53 5.08 ± 0.71 4.22 ± 1.85 4.87 ± 1.13
 TCH
(mmol/L)
1.41 ± 0.25 1.58 ± 0.33 1.54 ± 0.28 1.59 ± 0.23 1.37 ± 0.29 1.35 ± 0.28 1.44 ± 0.26 1.61 ± 0.25 1.31 ± 0.35 1.64 ± 0.17 1.49 ± 0.23 1.64 ± 0.11 1.44 ± 0.60 1.65 ± 0.20
 Cr
(umoL/L)
42.93 ± 3.31 40.01 ± 9.07 47.35 ± 2.92 45.48 ± 2.92 45.00 ± 2.29 39.76 ± 4.47 47.33 ± 2.92 45.60 ± 2.50 44.70 ± 2.61 42.92 ± 8.47 45.02 ± 6.74 46.32 ± 4.36 42.67 ± 0.70 45.72 ± 4.54
 Glu
(mmol/L)
4.50 ± 0.91 4.27 ± 1.07 5.61 ± 1.01 5.22 ± 0.86 4.29 ± 1.20 4.46 ± 1.26 5.56 ± 1.03 5.12 ± 0.59 4.17 ± 1.00 4.78 ± 0.61 4.89 ± 0.50 4.91 ± 0.53 5.55 ± 0.21 5.05 ± 0.46
 TP
(G/L)
75.05 ± 2.72 76.01 ± 1.66 75.02 ± 4.60 72.64 ± 3.10 75.07 ± 1.28 75.70 ± 3.35 74.99 ± 4.52 73.35 ± 2.66 74.70 ± 0.74 74.99 ± 2.84 76.01 ± 3.14 75.24 ± 3.29 75.09 ± 1.49 72.49 ± 0.60
 TG
(mmol/L)
1.42 ± 0.06 1.40 ± 0.04 1.43 ± 0.03 1.39 ± 0.06 1.43 ± 0.06 1.42 ± 0.10 1.42 ± 0.05 1.38 ± 0.05 1.46 ± 0.10 1.43 ± 0.08 1.43 ± 0.09 1.39 ± 0.06 1.46 ± 0.02 1.40 ± 0.04
Female
 Alb
(mmol/L)
35.30 ± 2.17 35.39 ± 2.16 36.36 ± 1.83 35.41 ± 2.12 35.36 ± 2.11 36.92 ± 1.52 36.10 ± 2.06 34.85 ± 2.06 34.62 ± 2.38 36.85 ± 2.33 35.59 ± 1.07 36.07 ± 1.23 36.40 ± 4.95 35.71 ± 2.30
 ALT
(U/L)
52.75 ± 6.31 52.31 ± 8.50 59.00 ± 10.26 57.66 ± 7.79 56.12 ± 7.66 51.37 ± 3.48 59.02 ± 10.33 60.49 ± 5.77 53.08 ± 7.40 56.82 ± 8.20 57.08 ± 6.03 56.16 ± 6.25 42.91 ± 0.14 58.76 ± 8.17
 AST
(U/L)
224.24 ± 30.90 225.92 ± 38.31 286.14 ± 39.24 239.81 ± 38.82 212.03 ± 14.14 247.89 ± 35.59 239.62 ± 5.35 240.87 ± 32.28 214.61 ± 19.90 226.69 ± 36.42 230.00 ± 33.50 242.82 ± 30.21 247.70 ± 46.71 226.45 ± 48.51
 BUN
(mmol/L)
5.35 ± 1.14 5.06 ± 1.16 4.71 ± 0.16 4.65 ± 0.66 5.11 ± 1.18 4.85 ± 0.81 3.68 ± 1.51 4.18 ± 0.87 5.27 ± 0.90 4.81 ± 0.49 4.35 ± 0.60 4.90 ± 0.58 5.67 ± 0.58 4.85 ± 1.09
 TCH
(mmol/L)
1.56 ± 0.50 1.49 ± 0.36 1.52 ± 0.46 1.64 ± 0.28 1.42 ± 0.43 1.43 ± 0.24 1.48 ± 0.54 1.60 ± 0.28 1.35 ± 0.16 1.44 ± 0.27 1.58 ± 0.15 1.66 ± 0.23 1.40 ± 0.24 1.65 ± 0.12
 Cr
(umoL/L)
44.75 ± 2.73 46.15 ± 3.65 44.45 ± 3.59 44.17 ± 4.06 43.90 ± 2.06 46.51 ± 4.38 44.38 ± 3.59 45.14 ± 3.15 42.57 ± 3.34 43.85 ± 5.03 46.65 ± 1.93 45.38 ± 2.46 40.09 ± 2.18 45.76 ± 4.44
 Glu
(mmol/L)
4.40 ± 1.16 4.29 ± 1.20 5.97 ± 0.42 5.37 ± 0.84 4.56 ± 0.63 5.00 ± 1.58 5.94 ± 0.51 5.16 ± 0.86 4.31 ± 1.12 4.93 ± 0.89 5.28 ± 0.70 4.74 ± 0.46 4.70 ± 2.13 5.03 ± 0.48
 TP
(G/L)
76.22 ± 3.76 75.17 ± 1.60 73.14 ± 3.68 74.29 ± 3.56 75.77 ± 2.03 76.31 ± 2.58 73.07 ± 3.61 73.35 ± 2.81 75.46 ± 1.26 74.11 ± 3.32 72.87 ± 2.04 71.97 ± 2.37 74.89 ± 0.98 72.46 ± 0.51
 TG
(mmol/L)
1.44 ± 0.09 1.43 ± 0.06 1.48 ± 0.01 1.40 ± 0.07 1.40 ± 0.14 1.36 ± 0.01 1.46 ± 0.05 1.42 ± 0.07 1.40 ± 0.03 1.36 ± 0.13 1.39 ± 0.05 1.34 ± 0.04 1.40 ± 0.04 1.41 ± 0.08
  1. Note: Control, Low, Middle and High refer to 0, 12, 60 and 300 mg/kg ethanamizuril dose. There were no statistically significant differences when the control and test article-treated groups were compared