From: Beagle dog 90-day oral toxicity study of a novel coccidiostat – ethanamizuril
Day 0 | Day 45 | day 90 | day 118 | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
High (n = 6) | Middle (n = 4) | Low(n = 4) | Control (n = 6) | High (n = 6) | Middle (n = 4) | Low (n = 4) | Control (n = 6) | High (n = 6) | Middle (n = 4) | Low (n = 4) | Control (n = 6) | High (n = 2) | Control (n = 2) | |
Male | ||||||||||||||
Alb (mmol/L) | 35.36 ± 2.16 | 35.42 ± 1.68 | 36.21 ± 3.89 | 36.07 ± 2.18 | 34.87 ± 1.75 | 36.49 ± 3.70 | 36.17 ± 3.82 | 36.67 ± 2.27 | 35.25 ± 1.65 | 35.75 ± 2.40 | 36.03 ± 1.98 | 36.20 ± 1.89 | 34.99 ± 1.24 | 35.71 ± 2.43 |
ALT (U/L) | 53.72 ± 6.47 | 56.87 ± 6.92 | 53.81 ± 5.10 | 57.92 ± 6.33 | 55.25 ± 6.62 | 54.40 ± 1.76 | 52.36 ± 2.56 | 57.66 ± 5.50 | 54.74 ± 5.93 | 51.90 ± 3.83 | 54.88 ± 6.36 | 55.44 ± 5.21 | 54.03 ± 7.75 | 58.77 ± 8.10 |
AST (U/L) | 219.07 ± 26.45 | 206.39 ± 36.90 | 253.82 ± 31.42 | 248.25 ± 37.59 | 226.79 ± 27.84 | 218.28 ± 12.53 | 255.55 ± 28.06 | 233.24 ± 32.73 | 220.40 ± 30.74 | 235.21 ± 49.83 | 235.09 ± 30.69 | 225.90 ± 37.02 | 275.27 ± 34.93 | 226.48 ± 58.58 |
BUN (mmol/L) | 5.06 ± 1.21 | 5.25 ± 1.39 | 4.85 ± 0.51 | 4.22 ± 0.88 | 5.25 ± 1.19 | 5.16 ± 1.09 | 5.33 ± 0.67 | 4.56 ± 0.74 | 5.63 ± 0.61 | 4.52 ± 0.94 | 5.07 ± 0.53 | 5.08 ± 0.71 | 4.22 ± 1.85 | 4.87 ± 1.13 |
TCH (mmol/L) | 1.41 ± 0.25 | 1.58 ± 0.33 | 1.54 ± 0.28 | 1.59 ± 0.23 | 1.37 ± 0.29 | 1.35 ± 0.28 | 1.44 ± 0.26 | 1.61 ± 0.25 | 1.31 ± 0.35 | 1.64 ± 0.17 | 1.49 ± 0.23 | 1.64 ± 0.11 | 1.44 ± 0.60 | 1.65 ± 0.20 |
Cr (umoL/L) | 42.93 ± 3.31 | 40.01 ± 9.07 | 47.35 ± 2.92 | 45.48 ± 2.92 | 45.00 ± 2.29 | 39.76 ± 4.47 | 47.33 ± 2.92 | 45.60 ± 2.50 | 44.70 ± 2.61 | 42.92 ± 8.47 | 45.02 ± 6.74 | 46.32 ± 4.36 | 42.67 ± 0.70 | 45.72 ± 4.54 |
Glu (mmol/L) | 4.50 ± 0.91 | 4.27 ± 1.07 | 5.61 ± 1.01 | 5.22 ± 0.86 | 4.29 ± 1.20 | 4.46 ± 1.26 | 5.56 ± 1.03 | 5.12 ± 0.59 | 4.17 ± 1.00 | 4.78 ± 0.61 | 4.89 ± 0.50 | 4.91 ± 0.53 | 5.55 ± 0.21 | 5.05 ± 0.46 |
TP (G/L) | 75.05 ± 2.72 | 76.01 ± 1.66 | 75.02 ± 4.60 | 72.64 ± 3.10 | 75.07 ± 1.28 | 75.70 ± 3.35 | 74.99 ± 4.52 | 73.35 ± 2.66 | 74.70 ± 0.74 | 74.99 ± 2.84 | 76.01 ± 3.14 | 75.24 ± 3.29 | 75.09 ± 1.49 | 72.49 ± 0.60 |
TG (mmol/L) | 1.42 ± 0.06 | 1.40 ± 0.04 | 1.43 ± 0.03 | 1.39 ± 0.06 | 1.43 ± 0.06 | 1.42 ± 0.10 | 1.42 ± 0.05 | 1.38 ± 0.05 | 1.46 ± 0.10 | 1.43 ± 0.08 | 1.43 ± 0.09 | 1.39 ± 0.06 | 1.46 ± 0.02 | 1.40 ± 0.04 |
Female | ||||||||||||||
Alb (mmol/L) | 35.30 ± 2.17 | 35.39 ± 2.16 | 36.36 ± 1.83 | 35.41 ± 2.12 | 35.36 ± 2.11 | 36.92 ± 1.52 | 36.10 ± 2.06 | 34.85 ± 2.06 | 34.62 ± 2.38 | 36.85 ± 2.33 | 35.59 ± 1.07 | 36.07 ± 1.23 | 36.40 ± 4.95 | 35.71 ± 2.30 |
ALT (U/L) | 52.75 ± 6.31 | 52.31 ± 8.50 | 59.00 ± 10.26 | 57.66 ± 7.79 | 56.12 ± 7.66 | 51.37 ± 3.48 | 59.02 ± 10.33 | 60.49 ± 5.77 | 53.08 ± 7.40 | 56.82 ± 8.20 | 57.08 ± 6.03 | 56.16 ± 6.25 | 42.91 ± 0.14 | 58.76 ± 8.17 |
AST (U/L) | 224.24 ± 30.90 | 225.92 ± 38.31 | 286.14 ± 39.24 | 239.81 ± 38.82 | 212.03 ± 14.14 | 247.89 ± 35.59 | 239.62 ± 5.35 | 240.87 ± 32.28 | 214.61 ± 19.90 | 226.69 ± 36.42 | 230.00 ± 33.50 | 242.82 ± 30.21 | 247.70 ± 46.71 | 226.45 ± 48.51 |
BUN (mmol/L) | 5.35 ± 1.14 | 5.06 ± 1.16 | 4.71 ± 0.16 | 4.65 ± 0.66 | 5.11 ± 1.18 | 4.85 ± 0.81 | 3.68 ± 1.51 | 4.18 ± 0.87 | 5.27 ± 0.90 | 4.81 ± 0.49 | 4.35 ± 0.60 | 4.90 ± 0.58 | 5.67 ± 0.58 | 4.85 ± 1.09 |
TCH (mmol/L) | 1.56 ± 0.50 | 1.49 ± 0.36 | 1.52 ± 0.46 | 1.64 ± 0.28 | 1.42 ± 0.43 | 1.43 ± 0.24 | 1.48 ± 0.54 | 1.60 ± 0.28 | 1.35 ± 0.16 | 1.44 ± 0.27 | 1.58 ± 0.15 | 1.66 ± 0.23 | 1.40 ± 0.24 | 1.65 ± 0.12 |
Cr (umoL/L) | 44.75 ± 2.73 | 46.15 ± 3.65 | 44.45 ± 3.59 | 44.17 ± 4.06 | 43.90 ± 2.06 | 46.51 ± 4.38 | 44.38 ± 3.59 | 45.14 ± 3.15 | 42.57 ± 3.34 | 43.85 ± 5.03 | 46.65 ± 1.93 | 45.38 ± 2.46 | 40.09 ± 2.18 | 45.76 ± 4.44 |
Glu (mmol/L) | 4.40 ± 1.16 | 4.29 ± 1.20 | 5.97 ± 0.42 | 5.37 ± 0.84 | 4.56 ± 0.63 | 5.00 ± 1.58 | 5.94 ± 0.51 | 5.16 ± 0.86 | 4.31 ± 1.12 | 4.93 ± 0.89 | 5.28 ± 0.70 | 4.74 ± 0.46 | 4.70 ± 2.13 | 5.03 ± 0.48 |
TP (G/L) | 76.22 ± 3.76 | 75.17 ± 1.60 | 73.14 ± 3.68 | 74.29 ± 3.56 | 75.77 ± 2.03 | 76.31 ± 2.58 | 73.07 ± 3.61 | 73.35 ± 2.81 | 75.46 ± 1.26 | 74.11 ± 3.32 | 72.87 ± 2.04 | 71.97 ± 2.37 | 74.89 ± 0.98 | 72.46 ± 0.51 |
TG (mmol/L) | 1.44 ± 0.09 | 1.43 ± 0.06 | 1.48 ± 0.01 | 1.40 ± 0.07 | 1.40 ± 0.14 | 1.36 ± 0.01 | 1.46 ± 0.05 | 1.42 ± 0.07 | 1.40 ± 0.03 | 1.36 ± 0.13 | 1.39 ± 0.05 | 1.34 ± 0.04 | 1.40 ± 0.04 | 1.41 ± 0.08 |