Table 2 Hematology of dogs on day 0, 45, 90 and 118
From: Beagle dog 90-day oral toxicity study of a novel coccidiostat – ethanamizuril
Day 0 | Day 45 | day 90 | day 118 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
High (n = 6) | Middle (n = 4) | Low(n = 4) | Control(n = 6) | High (n = 6) | Middle(n = 4) | Low(n = 4) | Control(n = 6) | High (n = 6) | Middle(n = 4) | Low(n = 4) | Control (n = 6) | High (n = 2) | Control (n = 2) | |
Male | ||||||||||||||
HGB (g/L) | 159.70 ± 6.69 | 163.01 ± 6.39 | 163.72 ± 9.32 | 158.80 ± 6.46 | 160.35 ± 6.68 | 165.09 ± 5.45 | 167.66 ± 13.93 | 156.32 ± 9.10 | 158.97 ± 8.14 | 166.93 ± 0.75 | 167.66 ± 13.9 | 155.09 ± 10.17 | 166.52 ± 1.67 | 156.55 ± 5.20 |
RBC (1012/L) | 7.66 ± 0.72 | 8.21 ± 0.30 | 8.03 ± 0.71 | 8.14 ± 0.62 | 7.52 ± 0.79 | 7.97 ± 0.54 | 8.02 ± 0.02 | 7.78 ± 0.55 | 7.38 ± 0.68 | 7.44 ± 0.10 | 8.02 ± 0.02 | 7.39 ± 0.21 | 7.35 ± 1.17 | 7.18 ± 0.18 |
WBC (109/L) | 13.21 ± 1.44 | 12.28 ± 1.44 | 12.29 ± 1.24 | 12.71 ± 1.51 | 12.70 ± 1.82 | 12.06 ± 1.39 | 12.14 ± 1.19 | 13.09 ± 1.52 | 11.99 ± 2.19 | 12.82 ± 1.52 | 12.14 ± 1.19 | 10.73 ± 0.45 | 13.90 ± 1.56 | 12.55 ± 2.40 |
PLT (109/L) | 670.20 ± 69.77 | 586.39 ± 7.75 | 687.71 ± 78.84 | 666.04 ± 91.36 | 649.40 ± 71.50 | 594.49 ± 98.53 | 710.70 ± 14.44 | 618.52 ± 69.15 | 668.92 ± 87.28 | 603.48 ± 24.83 | 710.70 ± 14.11 | 602.70 ± 79.93 | 392.35 ± 26.74 | 406.25 ± 136.81 |
HCT (%) | 47.88 ± 2.61 | 48.05 ± 3.58 | 46.59 ± 1.24 | 45.65 ± 1.84 | 47.72 ± 4.10 | 39.96 ± 5.63 | 47.35 ± 0.55 | 46.45 ± 1.88 | 46.83 ± 1.99 | 48.66 ± 2.88 | 47.35 ± 0.55 | 45.00 ± 2.45 | 44.01 ± 1.0 | 43.00 ± 3.0 |
EOS (109/L) | 1.11 ± 0.08 | 1.13 ± 0.03 | 1.11 ± 0.02 | 1.09 ± 0.04 | 1.13 ± 0.07 | 1.14 ± 0.08 | 1.26 ± 0.09 | 1.19 ± 0.15 | 1.16 ± 0.11 | 1.13 ± 0.05 | 1.26 ± 0.09 | 1.19 ± 0.25 | 1.69 ± 0.06 | 1.92 ± 0.09 |
BAS (109/L) | 0.11 ± 0.04 | 0.13 ± 0.04 | 0.15 ± 0.04 | 0.14 ± 0.04 | 0.09 ± 0.07 | 0.15 ± 0.07 | 0.12 ± 0.09 | 0.11 ± 0.04 | 0.16 ± 0.04 | 0.20 ± 0.06 | 0.12 ± 0.09 | 0.11 ± 0.08 | 0.09 ± 0.01 | 0.08 ± 0.01 |
NEU (109/L) | 1.65 ± 0.88 | 2.19 ± 0.31 | 2.42 ± 0.52 | 2.25 ± 0.70 | 1.41 ± 0.83 | 1.83 ± 0.83 | 2.46 ± 0.21 | 1.78 ± 0.48 | 1.65 ± 0.74 | 1.58 ± 0.03 | 2.46 ± 0.21 | 1.77 ± 0.24 | 1.30 ± 0.39 | 1.67 ± 0.22 |
MO (109/L) | 3.28 ± 0.12 | 3.26 ± 0.02 | 3.22 ± 0.13 | 3.19 ± 0.13 | 3.30 ± 0.11 | 3.28 ± 0.03 | 3.35 ± 0.05 | 3.25 ± 0.15 | 3.32 ± 0.09 | 3.32 ± 0.03 | 3.35 ± 0.05 | 3.32 ± 0.15 | 3.94 ± 0.14 | 3.92 ± 0.09 |
LYMPH (109/L) | 15.02 ± 0.44 | 14.53 ± 0.63 | 14.87 ± 0.44 | 14.69 ± 0.82 | 15.23 ± 0.46 | 14.70 ± 0.58 | 14.73 ± 0.83 | 14.77 ± 0.87 | 15.29 ± 0.47 | 14.60 ± 0.18 | 14.73 ± 0.83 | 14.43 ± 1.23 | 15.05 ± 0.81 | 14.82 ± 0.77 |
Female | ||||||||||||||
HGB (g/L) | 156.43 ± 6.99 | 165.17 ± 8.09 | 159.22 ± 14.25 | 160.26 ± 8.61 | 159.72 ± 6.46 | 163.54 ± 5.86 | 167.66 ± 14.01 | 160.17 ± 8.64 | 158.04 ± 6.94 | 159.74 ± 9.13 | 167.66 ± 14.01 | 157.24 ± 11.55 | 165.02 ± 11.04 | 165.02 ± 11.04 |
RBC (1012/L) | 7.61 ± 0.74 | 7.90 ± 0.78 | 8.02 ± 0.72 | 7.90 ± 0.60 | 7.72 ± 0.76 | 8.01 ± 0.50 | 7.54 ± 0.68 | 7.91 ± 0.59 | 7.60 ± 0.42 | 7.67 ± 0.87 | 7.54 ± 0.68 | 7.84 ± 0.33 | 7.51 ± 0.73 | 7.20 ± 0.16 |
WBC (109/L) | 13.66 ± 1.04 | 11.91 ± 1.57 | 12.64 ± 1.31 | 13.00 ± 1.65 | 13.39 ± 1.69 | 12.28 ± 1.81 | 12.89 ± 1.16 | 12.97 ± 1.60 | 12.08 ± 1.90 | 11.43 ± 0.72 | 12.89 ± 1.16 | 12.73 ± 2.96 | 12.67 ± 2.87 | 12.35 ± 2.45 |
PLT (109/L) | 701.46 ± 72.18 | 669.34 ± 90.59 | 667.61 ± 62.86 | 667.79 ± 83.58 | 682.98 ± 87.40 | 618.30 ± 59.51 | 659.86 ± 71.32 | 639.10 ± 71.15 | 653.87 ± 89.75 | 688.37 ± 91.20 | 659.86 ± 71.32 | 604.53 ± 61.83 | 427.35 ± 148.73 | 395.86 ± 133.91 |
HCT (%) | 47.34 ± 2.69 | 46.51 ± 2.54 | 48.63 ± 2.74 | 46.61 ± 2.45 | 46.93 ± 2.28 | 39.66 ± 5.44 | 45.11 ± 4.37 | 46.45 ± 1.95 | 46.13 ± 3.83 | 45.93 ± 4.04 | 45.11 ± 4.37 | 45.96 ± 1.57 | 42.01 ± 5.0 | 41.00 ± 2.0 |
EOS (109/L) | 1.13 ± 0.09 | 1.16 ± 0.14 | 1.13 ± 0.01 | 1.10 ± 0.07 | 1.14 ± 0.10 | 1.11 ± 0.05 | 1.20 ± 0.08 | 1.07 ± 0.07 | 1.14 ± 0.12 | 1.12 ± 0.03 | 1.20 ± 0.08 | 1.12 ± 0.03 | 1.39 ± 0.06 | 1.04 ± 0.14 |
BAS (109/L) | 0.11 ± 0.06 | 0.16 ± 0.14 | 0.14 ± 0.03 | 0.13 ± 0.03 | 0.09 ± 0.06 | 0.15 ± 0.05 | 0.11 ± 0.02 | 0.12 ± 0.14 | 0.10 ± 0.06 | 0.22 ± 0.11 | 0.11 ± 0.02 | 0.19 ± 0.11 | 0.09 ± 0.10 | 0.05 ± 0.03 |
NEU (109/L) | 1.71 ± 0.97 | 1.69 ± 0.34 | 2.37 ± 1.15 | 2.13 ± 0.63 | 1.66 ± 0.7 | 1.72 ± 0.12 | 2.43 ± 0.18 | 2.07 ± 0.66 | 1.74 ± 0.79 | 1.81 ± 0.46 | 2.43 ± 0.18 | 2.18 ± 0.64 | 2.00 ± 1.22 | 1.59 ± 0.21 |
MO (109/L) | 3.33 ± 0.9 | 3.29 ± 0.07 | 3.25 ± 0.08 | 3.26 ± 0.15 | 3.28 ± 0.08 | 3.24 ± 0.08 | 3.23 ± 0.13 | 3.26 ± 0.10 | 3.26 ± 0.06 | 3.25 ± 0.15 | 3.23 ± 0.13 | 3.24 ± 0.14 | 4.05 ± 0.15 | 4.04 ± 0.14 |
LYMPH (109/L) | 15.03 ± 0.43 | 14.73 ± 0.66 | 14.44 ± 0.74 | 14.76 ± 0.83 | 15.03 ± 0.50 | 14.46 ± 0.28 | 15.04 ± 0.96 | 14.95 ± 0.87 | 15.32 ± 0.49 | 14.96 ± 0.79 | 15.04 ± 0.96 | 14.52 ± 1.18 | 15.06 ± 0.81 | 14.86 ± 0.80 |