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Table 2 Hematology of dogs on day 0, 45, 90 and 118

From: Beagle dog 90-day oral toxicity study of a novel coccidiostat – ethanamizuril

  Day 0 Day 45 day 90 day 118
  High (n = 6) Middle (n = 4) Low(n = 4) Control(n = 6) High (n = 6) Middle(n = 4) Low(n = 4) Control(n = 6) High (n = 6) Middle(n = 4) Low(n = 4) Control (n = 6) High (n = 2) Control (n = 2)
Male
 HGB
(g/L)
159.70 ± 6.69 163.01 ± 6.39 163.72 ± 9.32 158.80 ± 6.46 160.35 ± 6.68 165.09 ± 5.45 167.66 ± 13.93 156.32 ± 9.10 158.97 ± 8.14 166.93 ± 0.75 167.66 ± 13.9 155.09 ± 10.17 166.52 ± 1.67 156.55 ± 5.20
 RBC
(1012/L)
7.66 ± 0.72 8.21 ± 0.30 8.03 ± 0.71 8.14 ± 0.62 7.52 ± 0.79 7.97 ± 0.54 8.02 ± 0.02 7.78 ± 0.55 7.38 ± 0.68 7.44 ± 0.10 8.02 ± 0.02 7.39 ± 0.21 7.35 ± 1.17 7.18 ± 0.18
 WBC
(109/L)
13.21 ± 1.44 12.28 ± 1.44 12.29 ± 1.24 12.71 ± 1.51 12.70 ± 1.82 12.06 ± 1.39 12.14 ± 1.19 13.09 ± 1.52 11.99 ± 2.19 12.82 ± 1.52 12.14 ± 1.19 10.73 ± 0.45 13.90 ± 1.56 12.55 ± 2.40
 PLT
(109/L)
670.20 ± 69.77 586.39 ± 7.75 687.71 ± 78.84 666.04 ± 91.36 649.40 ± 71.50 594.49 ± 98.53 710.70 ± 14.44 618.52 ± 69.15 668.92 ± 87.28 603.48 ± 24.83 710.70 ± 14.11 602.70 ± 79.93 392.35 ± 26.74 406.25 ± 136.81
 HCT
(%)
47.88 ± 2.61 48.05 ± 3.58 46.59 ± 1.24 45.65 ± 1.84 47.72 ± 4.10 39.96 ± 5.63 47.35 ± 0.55 46.45 ± 1.88 46.83 ± 1.99 48.66 ± 2.88 47.35 ± 0.55 45.00 ± 2.45 44.01 ± 1.0 43.00 ± 3.0
 EOS
(109/L)
1.11 ± 0.08 1.13 ± 0.03 1.11 ± 0.02 1.09 ± 0.04 1.13 ± 0.07 1.14 ± 0.08 1.26 ± 0.09 1.19 ± 0.15 1.16 ± 0.11 1.13 ± 0.05 1.26 ± 0.09 1.19 ± 0.25 1.69 ± 0.06 1.92 ± 0.09
 BAS
(109/L)
0.11 ± 0.04 0.13 ± 0.04 0.15 ± 0.04 0.14 ± 0.04 0.09 ± 0.07 0.15 ± 0.07 0.12 ± 0.09 0.11 ± 0.04 0.16 ± 0.04 0.20 ± 0.06 0.12 ± 0.09 0.11 ± 0.08 0.09 ± 0.01 0.08 ± 0.01
 NEU
(109/L)
1.65 ± 0.88 2.19 ± 0.31 2.42 ± 0.52 2.25 ± 0.70 1.41 ± 0.83 1.83 ± 0.83 2.46 ± 0.21 1.78 ± 0.48 1.65 ± 0.74 1.58 ± 0.03 2.46 ± 0.21 1.77 ± 0.24 1.30 ± 0.39 1.67 ± 0.22
 MO
(109/L)
3.28 ± 0.12 3.26 ± 0.02 3.22 ± 0.13 3.19 ± 0.13 3.30 ± 0.11 3.28 ± 0.03 3.35 ± 0.05 3.25 ± 0.15 3.32 ± 0.09 3.32 ± 0.03 3.35 ± 0.05 3.32 ± 0.15 3.94 ± 0.14 3.92 ± 0.09
 LYMPH
(109/L)
15.02 ± 0.44 14.53 ± 0.63 14.87 ± 0.44 14.69 ± 0.82 15.23 ± 0.46 14.70 ± 0.58 14.73 ± 0.83 14.77 ± 0.87 15.29 ± 0.47 14.60 ± 0.18 14.73 ± 0.83 14.43 ± 1.23 15.05 ± 0.81 14.82 ± 0.77
Female
 HGB
(g/L)
156.43 ± 6.99 165.17 ± 8.09 159.22 ± 14.25 160.26 ± 8.61 159.72 ± 6.46 163.54 ± 5.86 167.66 ± 14.01 160.17 ± 8.64 158.04 ± 6.94 159.74 ± 9.13 167.66 ± 14.01 157.24 ± 11.55 165.02 ± 11.04 165.02 ± 11.04
 RBC
(1012/L)
7.61 ± 0.74 7.90 ± 0.78 8.02 ± 0.72 7.90 ± 0.60 7.72 ± 0.76 8.01 ± 0.50 7.54 ± 0.68 7.91 ± 0.59 7.60 ± 0.42 7.67 ± 0.87 7.54 ± 0.68 7.84 ± 0.33 7.51 ± 0.73 7.20 ± 0.16
 WBC
(109/L)
13.66 ± 1.04 11.91 ± 1.57 12.64 ± 1.31 13.00 ± 1.65 13.39 ± 1.69 12.28 ± 1.81 12.89 ± 1.16 12.97 ± 1.60 12.08 ± 1.90 11.43 ± 0.72 12.89 ± 1.16 12.73 ± 2.96 12.67 ± 2.87 12.35 ± 2.45
 PLT
(109/L)
701.46 ± 72.18 669.34 ± 90.59 667.61 ± 62.86 667.79 ± 83.58 682.98 ± 87.40 618.30 ± 59.51 659.86 ± 71.32 639.10 ± 71.15 653.87 ± 89.75 688.37 ± 91.20 659.86 ± 71.32 604.53 ± 61.83 427.35 ± 148.73 395.86 ± 133.91
 HCT
(%)
47.34 ± 2.69 46.51 ± 2.54 48.63 ± 2.74 46.61 ± 2.45 46.93 ± 2.28 39.66 ± 5.44 45.11 ± 4.37 46.45 ± 1.95 46.13 ± 3.83 45.93 ± 4.04 45.11 ± 4.37 45.96 ± 1.57 42.01 ± 5.0 41.00 ± 2.0
 EOS
(109/L)
1.13 ± 0.09 1.16 ± 0.14 1.13 ± 0.01 1.10 ± 0.07 1.14 ± 0.10 1.11 ± 0.05 1.20 ± 0.08 1.07 ± 0.07 1.14 ± 0.12 1.12 ± 0.03 1.20 ± 0.08 1.12 ± 0.03 1.39 ± 0.06 1.04 ± 0.14
 BAS
(109/L)
0.11 ± 0.06 0.16 ± 0.14 0.14 ± 0.03 0.13 ± 0.03 0.09 ± 0.06 0.15 ± 0.05 0.11 ± 0.02 0.12 ± 0.14 0.10 ± 0.06 0.22 ± 0.11 0.11 ± 0.02 0.19 ± 0.11 0.09 ± 0.10 0.05 ± 0.03
 NEU
(109/L)
1.71 ± 0.97 1.69 ± 0.34 2.37 ± 1.15 2.13 ± 0.63 1.66 ± 0.7 1.72 ± 0.12 2.43 ± 0.18 2.07 ± 0.66 1.74 ± 0.79 1.81 ± 0.46 2.43 ± 0.18 2.18 ± 0.64 2.00 ± 1.22 1.59 ± 0.21
 MO
(109/L)
3.33 ± 0.9 3.29 ± 0.07 3.25 ± 0.08 3.26 ± 0.15 3.28 ± 0.08 3.24 ± 0.08 3.23 ± 0.13 3.26 ± 0.10 3.26 ± 0.06 3.25 ± 0.15 3.23 ± 0.13 3.24 ± 0.14 4.05 ± 0.15 4.04 ± 0.14
 LYMPH
(109/L)
15.03 ± 0.43 14.73 ± 0.66 14.44 ± 0.74 14.76 ± 0.83 15.03 ± 0.50 14.46 ± 0.28 15.04 ± 0.96 14.95 ± 0.87 15.32 ± 0.49 14.96 ± 0.79 15.04 ± 0.96 14.52 ± 1.18 15.06 ± 0.81 14.86 ± 0.80
  1. Note: Control, Low, Middle and High refer to 0, 12, 60 and 300 mg/kg ethanamizuril dose. There were no statistically significant differences when the control and test article-treated groups were compared