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Table 1 Selected clinical, hematological and echocardiographic parameters in dogs with different stages (Stages A, B2, C, and D) of heart failure. Mean ± SEM

From: Changes of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failure

Parameters Stage A
(n = 8)
Stage B2
(n = 6)
Stage C
(n = 10)
Stage D
(n = 5)
Clinical variables
 Age (years) 3.5 ± 0.3a 6.0 ± 1.6ab 8.6 ± 1.6 b* 9.1 ± 1.8 b**
 Body Weight (Kg) 23.5 ± 3.8 a 19.1 ± 4.7 a 16.0 ± 5.6 a 34.1 ± 8.5 a
 Gender (M/F) 2 / 6 2 / 4 6 / 4 3 / 2
Haematological variables
 WBC (×103/mm3) 11.5 ± 1.1a 10.1 ± 1.4a 18.4 ± 2.5b#** 18.7 ± 1.5b#**
 Neu (× 103/mm3) 7.9 ± 0.8 a 7.3 ± 0.9 a 14.4 ± 2.2 b** 15.7 ± 1.3b**
 cTnI ng/mL 0.03 ± 0.04 a 0.03 ± 0.03 a 1.80 ± 1.39 b*** 5.30 ± 2.01 c***
Echocardiographic variables
 RVd (cm) 0.62 ± 0.09 a 0.96 ± 0.11 a 0.97 ± 0.33 a 1.36 ± 0.35 a
 IVSd (cm) 0.9 ± 0.1 a 1.1 ± 0.1 a 0.7 ± 0.0 a 1.0 ± 0.1 a
 IVSs (cm) 1.1 ± 0.1 a 1.3 ± 0.1 a 0.9 ± 0.0 a 1.2 ± 0.1 a
 LVd (cm) 3.2 ± 0.2 a 3.0 ± 0.5 a 3.9 ± 0.4 a 5.7 ± 2.0 b#**
 LVs (cm) 2.2 ± 0.2 a 2.1 ± 0.1 a 2.8 ± 0.4 a 4.3 ± 0.8 b**#*
 PWd (cm) 1.0 ± 0.1 a 0.9 ± 0.1 a 0.6 ± 0.0 b** 0.9 ± 0.0 a
 PWs (cm) 1.2 ± 0.1 a 1.2 ± 0.1 a 0.7 ± 0.0 b*** 1.3 ± 0.1 a
 LA /Ao 1.1 ± 0.0 a 1.6 ± 0.1 b 2.2 ± 0.1 b#*** 2.3 ± 0.1 bc#***
 LVIDDn 1.38 ± 0.31a 1.72 ± 0.12 b** 1.78 ± 0.18bc** 2.03 ± 0.49c***#***
 MV E/A 1.9 ± 0.21 a 2.2 ± 0.2 ab 2.2 ± 0.1 ab 3.0 ± 0.5 b*
 EPSS (cm)
(DCM/MMVD)
0.2 ± 0.1a 0.4 ± 0.0a
(0.7 ± 0.3/0.2 ± 0.1+)
0.5 ± 0.1 ab
(1.2 ± 0.3/0.3 ± 0.1+)
1.2 ± 0.3 b*
(1.5 ± 0.4/0.4 ± 0.1+)
 FS (%)
(DCM/MMVD)
32 ± 2 a 35 ± 2a
(31 ± 3/38 ± 5)
29 ± 2 a
(16 ± 6/33 ± 7+)
26.7 ± 5.5 a
(16 ± 7/47 ± 9+)
  1. In the same rows, the difference between different letters was statistically significant, but the difference between all values with the same letter was not significant. * P < 0.05; ** P < 0.01; *** P < 0.001
  2. # Compared with Stage B2
  3. + Comparison between dilated cardiomyopathy (DCM) and myxomatous mitral valve disease (MMVD) (at least, P < 0.05)