Fig. 11

Therapeutic efficacy of Chol-37(F34-R) in S. aureus ATCC25923-infected mouse peritonitis model. a shows the lesions in lung and spleen of challenged mice treated with Chol-37(F34-R). b shows the pathological changes in the liver and spleen sections of mice challenged with S. aureus ATCC25923. c and d show histological scores of liver and spleen sections, respectively. Original magnification, Liver sections, × 40, spleen sections, × 40. The areas indicated by the arrows represent the type of lesion (a, necrosis; b, congestion; c, lymphocytic infiltration; d, hemorrhage; e, intumescentia). The measured resolution of each image was 300 × 300 DPI and the resolution of the combined image was 300 × 300 DPI. e and f show bacterial load of liver and spleen in mice, respectively. BP, benzylpenicillin potassium. The data are presented as means ± SD of results (n = 5). The number of bacteria (CFU) in the PBS group was defined as 100%, and the other groups are displayed proportionally compared with the PBS group. *, P < 0.05 and **, P < 0.01, compared with PBS. #, P < 0.05, compared with PMAP-37. §§, P < 0.01, compared with PMAP-37(F34-R). ns, nonsignificant difference