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Table 2 Antibacterial activity of the designed synthetic peptides against T. pyogenes and E. coli

From: Effect of intramolecular disulfide bond of bovine lactoferricin on its molecular structure and antibacterial activity against Trueperella pyogenes separated from cow milk with mastitis

Strain Antibacterial index Lfcin Lfcin DB Lfcin C36G
Trueperella pyogenes
isolate
MIC50 3.9 (1.2) 3.9 (1.2) 7.8 (2.5)
MIC90 7.8 (2.5) 3.9 (1.2) 15.6 (5.0)
MBC 7.8 (2.5) 3.9 (1.2) 15.6 (5.0)
Trueperella pyogenes
ATCC 19,411
MIC50 3.9 (1.2) 3.9 (1.2) 7.8 (2.5)
MIC90 3.9 (2.5) 3.9 (1.2) 7.8 (5.0)
MBC 7.8 (2.5) 3.9 (1.2) 15.6 (5.0)
Escherichia coli
ATCC 25,922
MIC50 62.5 (20.0) 125.0 (40.0) 125.0 (40.6)
MIC90 62.5 (20.0) 250.0 (80.0) 125.0 (40.6)
MBC 62.5 (20.0) 250.0 (80.0) 125.0 (40.6)
  1. Note: The MIC50 and MIC90 represent the concentrations required to inhibit 50 and 90% of the strains, respectively; MIC50, MIC90, and MBC in µg/mL (µM)