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Table 1 Pharmacokinetic parameters of SC, IM and IV administered buprenorphine in 10 New Zealand White Rabbits

From: Bioavailability of subcutaneous and intramuscular administrated buprenorphine in New Zealand White rabbits

PK parameter SC 0.05 mg/kg [mean (SD) range] IM 0.05 mg/kg [mean (SD) range] IV 0.05 mg/kg [mean (SD) range]
Cmax/C0 (ng/mL) 2.2 (1.4) 0.78–5.15 11 (3.2) 6.49–15.4*** 71 (44) 18–169
F (%) 50 (19) 26–82 95 (21) 53–113**
t½ (min) 260 (120) 138–495 148 (26) 113–191** 139 (33) 103–197**
tmax (min) 39 (60) 5–180 11 (5) 5–15
  1. SC subcutaneous, IM intramuscular, IV intravenous, Cmax maximum concentration (SC, IM), C0 calculated maximal concentration at time 0 (IV), F bioavailability, t½ elimination half-life, tmax time at maximum concentration. Cmax was compared between SC and IM routes. (**p < 0.01. ***p < 0.001 two-way ANOVA with route and sex as independent factors and animal and treatment day as blocking factors This was followed by planned comparisons on the predicted means to compare the IV and IM routes back to SC)