Fig. 1

Histology of different organs. a (1st line, left): mediastinum (H&E): severe multifocal, granulomatous inflammation with multinucleated giant cells and intralesional deposition of an acellular, extracellular, basophilic material. b (1st line, right): mediastinum, von Kossa stain showing the extracellular material in brown-black, indicating mineralisation. c (2nd line, left): lung (H&E): subpleural granulomatous inflammation with intralesional mineralisation. d (2nd line, right): lung: von Kossa stain, showing intralesional mineralisation in brown-black. (a-d, bars = 50 µm). e (3rd line, left): myocardium (H&E): within the myocardium, granulomatous inflammation with intralesional mineralisation is evident. f (3rd line, right): von Kossa stain showing intramyocardial mineralisation. g (4th line, left): small intestine (H&E): intramural granulomatous inflammation with intralesional mineralisation. h (4th line, right): small intestine, von Kossa stain, intramural mineralisation shown in brown-black. (e-h, bars = 100 µm)