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Fig. 5 | BMC Veterinary Research

Fig. 5

From: Bovine adapted transmissible mink encephalopathy is similar to L-BSE after passage through sheep with the VRQ/VRQ genotype but not VRQ/ARQ

Fig. 5

Immunohistochemistry. Patterns of PrPSc immunoreactivity in the brains of TgBovXV mice inoculated with (a) bTME, (b) L-BSE, (c) o-bTMEAV, (d) o-bTMEVV, and (e) C-BSE. There was diffuse immunoreactivity in the neuropil of the cerebral cortex, thalamus, hypothalamus, and hippocampus of bTME, L-BSE, o-bTMEAV, and o-bTMEVV. Granular particulate coalesces in the thalamus and cerebral cortex of b-TME, L-BSE, and o-bTMEAV. C-BSE contains PrPSc associated with plaques in the corpus collosum, hippocampus, thalamus, and hypothalamus. f A non-inoculated TgBovXV mouse had mild non-specific immunoreactivity in the polymorph layer of the dentate gyrus, cerebral cortex, endothelial cells, and choroid plexus epithelium. PrPSc detected with monoclonal antibody 6C2

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