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Table 2 Overview of the fecal pharmacokinetic (PK) parameters

From: The impact of therapeutic-dose induced intestinal enrofloxacin concentrations in healthy pigs on fecal Escherichia coli populations

PK parameters Group 1
PO
2.5 mg ENR/ kg BW
Group 2
PO
1.25 mg ENR/ kg BW
Group 3
IM
2.5 mg ENR/ kg BW
Group 4
IM
5 mg ENR/ kg BW
Cmax (μg/g) 17.75 ± 3.64a 5.11 ± 1.27b 15.00 ± 4.01a 24.14 ± 4.48c
Cmax/D 2.94 10− 4 ±
1.59 10− 4 a
2.6110− 4 ±
7.42 10− 5 a
3.67 10−4 ±
1.07 10− 4 a
2.97 10− 4 ±
1.17 10− 4 a
Cmin (μg/g) 6.53 ± 4.96a 4.32 ± 1.51a 5.21 ± 4.97a 7.92 ± 4.01a
AUC0–58hfeces
(h*μg/g)
775.93 ± 217.80a 299.34 ± 55.55b 808.01 ± 122.33a 1469.61 ± 502.00c
Cssfeces (μg/g) 12.94 ± 0.55a 4.51 ± 1.28b 10.64 ± 2.32a 19.53 ± 11.96c
  1. Overview of the area under the curve from 0 to 58 h (AUC0–58 h) for fecal concentrations, maximal and minimal fecal concentrations (Cmax and Cmin) and average steady state fecal concentrations (Cpssfecal) for groups 1, 2, 3 and 4. Linearity was checked by normalizing Cmax for dose (D) administered (Cmax/D). A difference in superscripts a, b or c denotes a statistical significant difference between these groups. Statistics were exerted using a single-factor ANOVA with a post-hoc Tukey test (equal variances checked), significance level 0.05. For Cmax/D an independent-samples T test was used to compare the mean values between group 1–2 and 3–4