Table 1 Overview of the pharmacokinetic (PK) parameters in plasma

C_max (μg/mL)

0.45 ± 0.080^a

0.18 ± 0.017^b

0.57 ± 0.14^a

1.02 ± 0.15^c

T_max (h)

2.25 ± 1.48^a

2.00 ± 0.63^a

2.50 ± 0.84^a

4.00 ± 2.10^a

AUC_{0–24 h} (h*μg/mL)

5.93 ± 1.16^a

2.02 ± 0.18^b

6.88 ± 1.93^a

12.26 ± 1.83^c

AUC_{0–58 h} (h*μg/mL)

14.98 ± 2.13^a

6.08 ± 1.40^b

16.13 ± 3.87^a

28.50 ± 3.65^c

AUC_{0–58 h}/D

8.96 10^− 4 ±

4.63 10^{− 4 a}

8.54 10^− 4 ±

6.66 10^{− 4 a}

8.59 10^− 4 ±

3.81 10^{− 4 a}

8.18 10^− 4 ±

2.45 10^{− 4 a}

Cp_ss (μg/mL)

0.25 ± 0.049^a

0.092 ± 0.021^b

0.29 ± 0.081^a

0.51 ± 0.076^c