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Table 1 Overview of the pharmacokinetic (PK) parameters in plasma

From: The impact of therapeutic-dose induced intestinal enrofloxacin concentrations in healthy pigs on fecal Escherichia coli populations

PK parameters Group 1
PO
2.5 mg ENR/ kg BW
Group 2
PO
1.25 mg ENR/ kg BW
Group 3
IM
2.5 mg ENR/ kg BW
Group 4
IM
5 mg ENR/ kg BW
Cmax (μg/mL) 0.45 ± 0.080a 0.18 ± 0.017b 0.57 ± 0.14a 1.02 ± 0.15c
Tmax (h) 2.25 ± 1.48a 2.00 ± 0.63a 2.50 ± 0.84a 4.00 ± 2.10a
AUC0–24 h (h*μg/mL) 5.93 ± 1.16a 2.02 ± 0.18b 6.88 ± 1.93a 12.26 ± 1.83c
AUC0–58 h (h*μg/mL) 14.98 ± 2.13a 6.08 ± 1.40b 16.13 ± 3.87a 28.50 ± 3.65c
AUC0–58 h/D 8.96 10− 4 ±
4.63 10− 4 a
8.54 10− 4 ±
6.66 10− 4 a
8.59 10− 4 ±
3.81 10− 4 a
8.18 10− 4 ±
2.45 10− 4 a
Cpss (μg/mL) 0.25 ± 0.049a 0.092 ± 0.021b 0.29 ± 0.081a 0.51 ± 0.076c
  1. Overview of the area under the curve from 0 to 24 h (AUC0–24 h), maximal plasma concentration of ENR (Cmax), and time of Cmax (Tmax) for groups 1, 2, 3 and 4 after the first administration (0–24 h). Also, the AUC0–58 h values (3 treatment days days), AUC0–58 h values normalized for dose (D) administered (AUC0–58 h/D) and the steady state plasma concentrations (Cpss) for groups 1, 2, 3 and 4 are given. A difference in superscripts a, b or c denotes a statistical significant difference between these groups. Statistics were exerted using a single-factor ANOVA with a post-hoc Tukey test (equality of variances checked), significance level 0.05. For AUC0–58h/D an independent-samples T test was used to compare the mean values between group 1–2 and 3–4