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Table 3 PK/PD analysis of data acquired from ex vivo time-killing curve of ceftiofur against a representative strain of APP BW39 in serums

From: Optimal regimens based on PK/PD cutoff evaluation of ceftiofur against Actinobacillus pleuropneumoniae in swine

Parameter

Unit

healthy

Emax

Log10 CFU/ml

3.68

E0

Log10 CFU/ml

−6.88

Emax-E0

Log10 CFU/ml

10.56

EC50

h

21.97

N

–

1.78

AUC 24 h /MIC for bacteriostatic

h

45.73

AUC 24 h /MIC for bactericidal

h

63.83

AUC 24 h /MIC for elimination

h

69.04