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Table 8 Skin temperature, thermal threshold (TT) and thermal excursion (%TE) and ambient temperature following a single IV administration of saline, 0.25, 0.5 and 1.0 mg/kg meperidine HCl to 8 horses. Values are expressed as mean ± SD

From: Meperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses

Dose Group Time (h)
  0 0.25 0.5 0.75 1 1.5 2 3 4 6
Skin Temp (°C)
  Saline 24.6 ± 3.1 25.2 ± 3.1 26.3 ± 3.4* 26.7 ± 3.2* 27.3 ± 3.3* 28.2 ± 3.1* 29.3 ± 2.9* 30.5 ± 1.9* 32.0 ± 2.0* 32.0 ± 2.0*
  0.25 mg/kg 24.8 ± 1.7 24.8 ± 2.3 25.9 ± 2.5 26.2 ± 2.8 28.1 ± 3.3* 28.5 ± 3.6* 29.2 ± 4.0* 28.8 ± 4.2* 29.7 ± 4.0* 30.6 ± 4.6*
  0.5 mg/kg 25.4 ± 3.2 25.4 ± 3.7 27.4 ± 3.8* 28.1 ± 4.0* 29.7 ± 2.4* 30.4 ± 1.6* 31.3 ± 1.0* 31.6 ± 0.9* 32.1 ± 1.0* 32.1 ± 1.4*
  1 mg/kg 25.4 ± 2.3 25.9 ± 2.8 26.5 ± 3.3 27.5 ± 2.8* 28.7 ± 1.7* 31.3 ± 3.8* 30.8 ± 1.0* 30.3 ± 1.7* 30.7 ± 2.1* 32.1 ± 0.8*
TT (°C)
  Saline 48.5 ± 4.9 50.0 ± 4.2 48.6 ± 6.9 46.7 ± 6.5 50.0 ± 7.8 47.6 ± 3.7 49.9 ± 3.7 50.0 ± 6.3 49.4 ± 4.8 50.6 ± 4.7
  0.25 mg/kg 49.6 ± 3.8 50.3 ± 3.2 46.9 ± 6.9 51.4 ± 4.3 51.0 ± 4.8 51.7 ± 4.3 49.5 ± 5.4 50.7 ± 5.0 51.4 ± 5.9 52.8 ± 3.3
  0.5 mg/kg 47.7 ± 6.0 51.7 ± 3.6* 50.5 ± 4.5* 50.8 ± 5.5* 49.9 ± 4.0 47.4 ± 5.3 47.4 ± 4.3 48.7 ± 5.9 51.5 ± 4.0* 49.7 ± 3.7
  1 mg/kg 49.0 ± 3.4 53.5 ± 2.6* 51.3 ± 3.6 48.9 ± 5.6 50.4 ± 3.1 50.6 ± 5.5 47.8 ± 4.9 47.9 ± 3.1 49.3 ± 4.3 48.9 ± 6.4
% TE
  Saline 79.4 ± 15.2 83.4 ± 13.2 78.6 ± 21.8 70.5 ± 24.5 81.9 ± 28.3 71.6 ± 14.1 79.8 ± 14.6 78.9 ± 26.7 75.6 ± 21.4 80.2 ± 21.2
  0.25 mg/kg 82.1 ± 12.2 84.3 ± 10.8 70.6 ± 26.0 87.4 ± 15.1 84.2 ± 18.7 86.2 ± 17.6 76.4 ± 23.1 82.9 ± 18.5 84.9 ± 24.3 90.1 ± 14.3
  0.5 mg/kg 75.4 ± 20.9 88.6 ± 12.8* 84.2 ± 15.7* 84.9 ± 20.7* 79.7 ± 16.0 69.3 ± 21.4 67.7 ± 18.3 73.1 ± 25.3 84.6 ± 17.9 76.8 ± 16.5
  1 mg/kg 79.7 ± 11.3 94.9 ± 8.9* 87.3 ± 12.4 78.4 ± 19.0 82.4 ± 12.1 81.6 ± 23.0 70.2 ± 20.4 71.1 ± 12.5 76.6 ± 18.0 73.3 ± 27.2
Ambient Temp (°C)
  Saline 19.4 ± 1.2 20.0 ± 1.0* 20.1 ± 1.0* 20.3 ± 1.1* 20.4 ± 1.0* 20.8 ± 1.0* 21.1 ± 1.1* 22.2 ± 1.2* 23.4 ± 1.4* 25.8 ± 1.4*
  0.25 mg/kg 20.9 ± 1.9 20.8 ± 1.8 20.9 ± 1.9 21.1 ± 1.9 21.1 ± 1.9 21.4 ± 2.0 21.8 ± 2.1* 22.6 ± 2.2* 23.6 ± 2.0* 25.0 ± 1.3*
  0.5 mg/kg 19.9 ± 2.1 20.2 ± 1.9 20.4 ± 2.0 20.7 ± 2.0 20.9 ± 2.0* 21.4 ± 1.9* 21.9 ± 1.9* 22.9 ± 2.0* 23.8 ± 2.0* 24.7 ± 1.5*
  1 mg/kg 20.5 ± 1.4 20.6 ± 1.2 20.8 ± 1.2 20.9 ± 1.2* 21.1 ± 1.2* 21.6 ± 1.2* 22.1 ± 1.1* 23.1 ± 1.2* 24.1 ± 1.1* 26.1 ± 1.4*
  1. *, indicates a significant difference (p < .05) relative to baseline