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Table 6 Packed cell volume (PCV) and total plasma protein (TP), mean ± SD, following a single IV administration of meperidine HCl (0.25, 0.5 and 1.0 mg/kg) to adult horses

From: Meperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses

Time (h) Saline
(n = 8)
0.25 mg/kg
(n = 7)
0.5 mg/kg
(n = 8)
1.0 mg/kg
(n = 8)
PCV
(%)
TP
(g 100 mL− 1)
PCV
(%)
TP
(g 100 mL− 1)
PCV
(%)
TP
(g 100 mL− 1)
PCV (%) TP
(g 100 mL− 1)
Baseline 35.5 ± 1.4 6.3 ± 0.2 35.5 ± 2.4 6.2 ± 0.4 35.2 ± 2.2 6.2 ± 0.3 36.0 ± 1.9 6.2 ± 0.3
0.08 34.9 ± 1.3 6.4 ± 0.2 34.9 ± 1.9 6.2 ± 0.3 37.0 ± 3.8 6.2 ± 0.3 41.1 ± 6.3* 6.2 ± 0.3
0.16 34.8 ± 1.4 6.4 ± 0.2 34.0 ± 1.9* 6.2 ± 0.3 35.7 ± 3.6 6.2 ± 0.3 39.4 ± 5.4* 6.1 ± 0.3
0.25 35.0 ± 1.9 6.4 ± 0.3 34.0 ± 1.5* 6.2 ± 0.3 35.5 ± 2.8 6.2 ± 0.3 38.1 ± 4.6 6.1 ± 0.3
0.5 35.0 ± 2.0 6.4 ± 0.3 33.9 ± 1.1* 6.3 ± 0.3 34.6 ± 1.6 6.3 ± 0.3* 36.0 ± 3.0 6.1 ± 0.3
0.75 35.4 ± 1.6 6.4 ± 0.3 35.1 ± 2.5 6.4 ± 0.4* 36.6 ± 2.8 6.4 ± 0.3* 36.3 ± 2.9 6.2 ± 0.4
1 35.3 ± 1.9 6.5 ± 0.3 34.8 ± 1.2 6.4 ± 0.4* 35.8 ± 2.0 6.5 ± 0.4* 36.7 ± 3.6 6.3 ± 0.4
2 35.5 ± 1.4 6.4 ± 0.2 35.3 ± 1.0 6.3 ± 0.4 35.4 ± 2.3 6.4 ± 0.4* 36.2 ± 2.7 6.2 ± 0.5
4 36.2 ± 3.2 6.3 ± 0.3 34.8 ± 1.7 6.3 ± 0.3 35.3 ± 2.5 6.3 ± 0.3 36.1 ± 1.8 6.1 ± 0.4
6 36.1 ± 3.2 6.3 ± 0.2 35.1 ± 1.6 6.2 ± 0.2 35.8 ± 2.5 6.3 ± 0.3 36.0 ± 2.2 6.2 ± 0.4
  1. *, indicates a significant difference (p < .05) relative to baseline