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Table 6 Packed cell volume (PCV) and total plasma protein (TP), mean ± SD, following a single IV administration of meperidine HCl (0.25, 0.5 and 1.0 mg/kg) to adult horses

From: Meperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses

Time (h)

Saline

(n = 8)

0.25 mg/kg

(n = 7)

0.5 mg/kg

(n = 8)

1.0 mg/kg

(n = 8)

PCV

(%)

TP

(g 100 mL− 1)

PCV

(%)

TP

(g 100 mL− 1)

PCV

(%)

TP

(g 100 mL− 1)

PCV (%)

TP

(g 100 mL− 1)

Baseline

35.5 ± 1.4

6.3 ± 0.2

35.5 ± 2.4

6.2 ± 0.4

35.2 ± 2.2

6.2 ± 0.3

36.0 ± 1.9

6.2 ± 0.3

0.08

34.9 ± 1.3

6.4 ± 0.2

34.9 ± 1.9

6.2 ± 0.3

37.0 ± 3.8

6.2 ± 0.3

41.1 ± 6.3*

6.2 ± 0.3

0.16

34.8 ± 1.4

6.4 ± 0.2

34.0 ± 1.9*

6.2 ± 0.3

35.7 ± 3.6

6.2 ± 0.3

39.4 ± 5.4*

6.1 ± 0.3

0.25

35.0 ± 1.9

6.4 ± 0.3

34.0 ± 1.5*

6.2 ± 0.3

35.5 ± 2.8

6.2 ± 0.3

38.1 ± 4.6

6.1 ± 0.3

0.5

35.0 ± 2.0

6.4 ± 0.3

33.9 ± 1.1*

6.3 ± 0.3

34.6 ± 1.6

6.3 ± 0.3*

36.0 ± 3.0

6.1 ± 0.3

0.75

35.4 ± 1.6

6.4 ± 0.3

35.1 ± 2.5

6.4 ± 0.4*

36.6 ± 2.8

6.4 ± 0.3*

36.3 ± 2.9

6.2 ± 0.4

1

35.3 ± 1.9

6.5 ± 0.3

34.8 ± 1.2

6.4 ± 0.4*

35.8 ± 2.0

6.5 ± 0.4*

36.7 ± 3.6

6.3 ± 0.4

2

35.5 ± 1.4

6.4 ± 0.2

35.3 ± 1.0

6.3 ± 0.4

35.4 ± 2.3

6.4 ± 0.4*

36.2 ± 2.7

6.2 ± 0.5

4

36.2 ± 3.2

6.3 ± 0.3

34.8 ± 1.7

6.3 ± 0.3

35.3 ± 2.5

6.3 ± 0.3

36.1 ± 1.8

6.1 ± 0.4

6

36.1 ± 3.2

6.3 ± 0.2

35.1 ± 1.6

6.2 ± 0.2

35.8 ± 2.5

6.3 ± 0.3

36.0 ± 2.2

6.2 ± 0.4

  1. *, indicates a significant difference (p < .05) relative to baseline