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Table 4 Mean ± SD urine concentrations of meperidine and normeperidine following a single IV administration of meperidine HCl (0.25, 0.5 and 1.0 mg/kg) to adult horses

From: Meperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses

  Meperidine concentration (ng/mL) Normeperidine concentration (ng/mL)
0.25 mg/kg(n = 7) 0.5 mg/kg(n = 8) 1.0 mg/kg(n = 8) 0.25 mg/kg(n = 7) 0.5 mg/kg(n = 8) 1.0 mg/kg(n = 8)
4 hours 135.2 ± 53.5 993.5 ± 1822.7 1142.6 ± 912.9 153.1 ± 120.4 956.8 ± 1646.6 1217.8 ± 1319.0
24 hours ND 1.51 ± 0.82 4.42 ± 5.89 1.13 ± 0.17 (n = 3) 1.80 ± 0.60 4.70 ± 5.67
48 hours ND ND ND ND 0.37 ± 0 (n = 1) 0.48 ± 0.12 (n = 3)
72 hours ND ND ND ND ND ND
96 hours ND ND ND ND ND ND
  1. ND Not detected