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Table 4 Mean ± SD urine concentrations of meperidine and normeperidine following a single IV administration of meperidine HCl (0.25, 0.5 and 1.0 mg/kg) to adult horses

From: Meperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses

 

Meperidine concentration (ng/mL)

Normeperidine concentration (ng/mL)

0.25 mg/kg(n = 7)

0.5 mg/kg(n = 8)

1.0 mg/kg(n = 8)

0.25 mg/kg(n = 7)

0.5 mg/kg(n = 8)

1.0 mg/kg(n = 8)

4 hours

135.2 ± 53.5

993.5 ± 1822.7

1142.6 ± 912.9

153.1 ± 120.4

956.8 ± 1646.6

1217.8 ± 1319.0

24 hours

ND

1.51 ± 0.82

4.42 ± 5.89

1.13 ± 0.17 (n = 3)

1.80 ± 0.60

4.70 ± 5.67

48 hours

ND

ND

ND

ND

0.37 ± 0 (n = 1)

0.48 ± 0.12 (n = 3)

72 hours

ND

ND

ND

ND

ND

ND

96 hours

ND

ND

ND

ND

ND

ND

  1. ND Not detected