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Table 3 Pharmacokinetic parameters (mean ± SD) for normeperidine following a single IV administration of meperidine HCl (0.25, 0.5 and 1.0 mg/kg) to adult horses. All values reported were generated using non-compartmental analysis

From: Meperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses

Parameters

Dose Groups

0.25 mg/kg

(n = 7)

0.5 mg/kg

(n = 8)

1.0 mg/kg

(n = 8)

Cmax ng/mL

4.27 ± 2.07

6.23 ± 2.62

11.2 ± 5.64

Tmax (h)

0.14 ± 0.06

0.22 ± 0.24

0.14 ± 0.06

Lambdaz(1/h)

0.307 ± 0.010

0.272 ± 0.054

0.271 ± 0.054

HL Lambdaz (h)

2.39 ± 0.498

2.63 ± 0.449

2.63 ± 0.449

AUC0 − inf (h*ng/mL)

7.35 ± 1.58

17.8 ± 9.26

35.6 ± 17.8

  1. Cmax maximum measured concentration; Tmax, time of maximum concentration; Lambdaz, terminal slope; HL Lambdaz, terminal half-life; AUC0 − inf, area under the plasma-concentration curve from time 0 to infinity
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BMC Veterinary Research

ISSN: 1746-6148

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