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Table 3 Pharmacokinetic parameters (mean ± SD) for normeperidine following a single IV administration of meperidine HCl (0.25, 0.5 and 1.0 mg/kg) to adult horses. All values reported were generated using non-compartmental analysis

From: Meperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses

Parameters Dose Groups
0.25 mg/kg
(n = 7)
0.5 mg/kg
(n = 8)
1.0 mg/kg
(n = 8)
Cmax ng/mL 4.27 ± 2.07 6.23 ± 2.62 11.2 ± 5.64
Tmax (h) 0.14 ± 0.06 0.22 ± 0.24 0.14 ± 0.06
Lambdaz(1/h) 0.307 ± 0.010 0.272 ± 0.054 0.271 ± 0.054
HL Lambdaz (h) 2.39 ± 0.498 2.63 ± 0.449 2.63 ± 0.449
AUC0 − inf (h*ng/mL) 7.35 ± 1.58 17.8 ± 9.26 35.6 ± 17.8
  1. Cmax maximum measured concentration; Tmax, time of maximum concentration; Lambdaz, terminal slope; HL Lambdaz, terminal half-life; AUC0 − inf, area under the plasma-concentration curve from time 0 to infinity