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Table 2 Pharmacokinetic parameters (mean ± SD) for meperidine following a single IV administration of meperidine HCl (0.25, 0.5 and 1.0 mg/kg) to adult horses. All values reported were generated using non-compartmental analysis

From: Meperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses

Parameters Dose Groups
0.25 mg/kg
(n = 7)
0.5 mg/kg
(n = 8)
1.0 mg/kg
(n = 8)
C(0) ng/mL 540.9 ± 142.9c 691.9 ± 123.1c 987.7 ± 224.6ab
Lambdaz(1/h) 0.358 ± 0.157b 0.245 ± 0.139a 0.207 ± 0.062
HL Lambdaz (h) 1.93 ± 1.39c 2.82 ± 2.10 3.35 ± 0.940a
Vdss (L/kg) 0.829 ± 0.138bc 1.08 ± 0.194ac 1.58 ± 0.280ab
CL (mL/min/kg) 18.0 ± 1.40c 19.3 ± 3.03c 22.8 ± 3.60ab
AUC0 − inf (h*ng/mL) 232.7 ± 19.4bc 442.8 ± 73.1ac 748.3 ± 125.5ab
  1. C(0) Concentration extrapolated to the origin, Lambdaz, terminal slope; HL Lambdaz, terminal half-life, Vdss Volume of distribution at steady-state, CL Clearance, AUC0 − inf, Area under the plasma-concentration curve from time 0 to infinity
  2. asignificantly different (p < .05) from 0.25 mg/kg 
  3. bsignificantly different (p < .05) from 0.5 mg/kg
  4. csignificantly different (p < .05) from 1.0 mg/kg