Table 2 Pharmacokinetic parameters (mean ± SD) for meperidine following a single IV administration of meperidine HCl (0.25, 0.5 and 1.0 mg/kg) to adult horses. All values reported were generated using non-compartmental analysis

C(0) ng/mL

540.9 ± 142.9^c

691.9 ± 123.1^c

987.7 ± 224.6^ab

Lambda_z(1/h)

0.358 ± 0.157^b

0.245 ± 0.139^a

0.207 ± 0.062

HL Lambda_z (h)

1.93 ± 1.39^c

2.82 ± 2.10

3.35 ± 0.940^a

Vdss (L/kg)

0.829 ± 0.138^bc

1.08 ± 0.194a^c

1.58 ± 0.280^ab

CL (mL/min/kg)

18.0 ± 1.40^c

19.3 ± 3.03^c

22.8 ± 3.60^ab

AUC_{0 − inf} (h*ng/mL)

232.7 ± 19.4^bc

442.8 ± 73.1^ac

748.3 ± 125.5^ab