Table 1 Accuracy and precision values for LC-MS/MS analysis of meperidine and normeperidine in plasma and urine
Drug | Matrix | Concentration (µg/mL) | Intra-day accuracy (% nominal concentration) | Intra-day precision (% relative SD) | Inter-day accuracy (% nominal concentration) | Inter-day precision (% relative SD) |
|---|---|---|---|---|---|---|
Meperidine | ||||||
Plasma | 0.3 | 113 | 3.0 | 106 | 2.0 | |
40.0 | 100 | 1.0 | 103 | 1.0 | ||
1000 | 88.0 | 2.0 | 89.0 | 3.0 | ||
Urine | 0.75 | 95.0 | 4.0 | 99.0 | 5.0 | |
50.0 | 100 | 3.0 | 103 | 10.0 | ||
1000 | 100 | 4.0 | 104 | 5.0 | ||
Normeperidine | ||||||
Plasma | 0.3 | 103 | 4.0 | 99.0 | 5.0 | |
40.0 | 100 | 2.0 | 102 | 2.0 | ||
1000 | 99.0 | 3.0 | 104 | 3.0 | ||
Urine | 0.75 | 103 | 3.0 | 101 | 5.0 | |
50.0 | 105 | 2.0 | 106 | 2.0 | ||
1000 | 100 | 4.0 | 105 | 3.0 | ||