Skip to main content

Table 1 Accuracy and precision values for LC-MS/MS analysis of meperidine and normeperidine in plasma and urine

From: Meperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses

Drug Matrix Concentration
(µg/mL)
Intra-day accuracy (% nominal concentration) Intra-day precision
(% relative SD)
Inter-day accuracy (% nominal concentration) Inter-day precision
(% relative SD)
Meperidine
  Plasma 0.3 113 3.0 106 2.0
   40.0 100 1.0 103 1.0
   1000 88.0 2.0 89.0 3.0
  Urine 0.75 95.0 4.0 99.0 5.0
   50.0 100 3.0 103 10.0
   1000 100 4.0 104 5.0
Normeperidine
  Plasma 0.3 103 4.0 99.0 5.0
   40.0 100 2.0 102 2.0
   1000 99.0 3.0 104 3.0
  Urine 0.75 103 3.0 101 5.0
   50.0 105 2.0 106 2.0
   1000 100 4.0 105 3.0