Lysophosphatidic acid as a regulator of endometrial connective tissue growth factor and prostaglandin secretion during estrous cycle and endometrosis in the mare

Table 1 Basal secretion (mean ± standard deviation) of prostaglandin (PG)E₂, PGF_2α and connective tissue growth factor (CTGF) from equine endometrium in mid-luteal phase and follicular phase of the estrous cycle at different stages of endometrosis. Superscript letters indicate significant differences between different stages of endometrosis within each phase of estrous cycle

	mid-luteal phase of estrous cycle
Category according to Kenney and Doig	I	II A	II B	III
PGE₂ (ng/g tissue)	408.54 ± 42.04^a	1116 ± 405.1^b	1201 ± 111.5^b	2090 ± 211.4^c
PGF_2α (ng/g tissue)	1590 ± 222.1^a	1895 ± 311.4^a	2907 ± 567.4^b	1865 ± 401.1^a
CTGF (ng/g tissue)	8.148 ± 3.27^a	6.563 ± 0.864^a	6.076 ± 4.007^a	6.123 ± 1.511^a
	follicular phase of estrous cycle
PGE₂ (ng/g tissue)	1460 ± 494.9^a	2374 ± 385.3^ab	1657 ± 365.1^a	4296 ± 2307^b
PGF_2α (ng/g tissue)	1310 ± 225.2^a	1586 ± 285.6^ab	2245 ± 636.8^ab	3237 ± 1793^b
CTGF (ng/g tissue)	5.717 ± 3.534^a	4.510 ± 1.300^a	7.399 ± 3.692^a	4.710 ± 1.001^a

ISSN: 1746-6148