Table 1 Plasma pharmacokinetic parameters following intramuscular administration of either flunixin meglumine 2.2 mg/kg (n = 6) or meloxicam 0.4 mg/kg (n = 7)

Dose

mg/kg

2.20

0.40

MRT

h

5.63

(3.44–8.58)

4.15

(3.23–6.37)

T _1/2

h

5.41

(3.01–9.34)

3.34

(2.35–6.37)

λ _z

h

0.13

(0.07–0.23)

0.21

(0.11–0.29)

T _max

1/h

0.22

(0.08–0.75)

0.37

(0.17–1.50)

C _max

µg/mL

2.18

(1.82–2.87)

1.20

(0.75–2.85)

AUC _last

h*µg/mL

5.96

(3.95–7.83)

4.63

(3.01–8.55)

AUC _inf

h*µg/mL

5.97

(3.97–7.85)

4.65

(3.02–8.67)

AUC _extrap

%

0.23

(0.10–0.38)

0.31

(0.10–1.31)

Vd/F

L/kg

2.88

(1.22–7.47)

0.41

(0.23–0.58)

Cl/F

L/h/kg

0.37

(0.28–0.55)

0.09

(0.05–0.13)