Safety evaluation of the interchangeable use of robenacoxib in commercially-available tablets and solution for injection in cats

Table 7 Study design used to evaluate the safety of interchangeable use of oral and subcutaneous administration of robenacoxib in cats

Dosing Cycle	Study Day	Route of administration	Dosing Regimen x (Multiplication Factor^a)
1	1 to 7	Oral	≥2.4 mg/kg/day X (0,1,2,3)
1	8 to 10	SC	2.0 mg/kg/day X (0,1,2,3)
2	11 to 17	Oral	≥2.4 mg/kg/day X (0,1,2,3)
2	18 to 20	SC	2.0 mg/kg/day X (0,1,2,3)
3	21 to 27	Oral	≥2.4 mg/kg/day X (0,1,2,3)
3	28 to 30	SC	2.0 mg/kg/day X (0,1,2,3)
4	31 to 37	Oral	≥2.4 mg/kg/day X (0,1,2,3)

^aMultiplication factors were applied to the dose in treated groups (i.e. Group 4 corresponds to 3X the MRD or 3 X ≥2.4 mg/kg/day = ≥7.2 mg/kg/day oral administration)

ISSN: 1746-6148