Table 4 Summary of post-treatment means (± SD) of clinical chemistry variables (average of days 13 and 37)

Sodium [mEq/L]

146 – 160

150.6 ± 1.1

150.3 ± 1.3

150.5 ± 1.4

150.6 ± 1.5

Potassium [mEq/L]^b

4.6 - 7.4

5.55 ± 0.64

5.40 ± 0.24

5.33 ± 0.41

5.50 ± 0.43

Chloride [mEq/L]

112 – 123

116.00 ± 1.78

116.63 ± 1.50

115.88 ± 1.71

115.81 ± 1.97

Calcium [mg/dL]

9.6 - 11.5

10.25 ± 0.33

10.01 ± 0.31

10.16 ± 0.26

10.17 ± 0.26

Phosphorus [mg/dL]*

6.2 - 9.7

8.89 ± 0.88

8.86 ± 0.76

8.18 ± 0.83

8.66 ± 0.78

Alkaline Phosphatase [U/L]

50 – 186

102.9 ± 34.3

105.6 ± 40.6

94.5 ± 24.4

90.0 ± 19.5

Total Bilirubin [mg/dL]

0 - 0.3

0.19 ± 0.04

0.18 ± 0.04

0.19 ± 0.03

0.19 ± 0.03

GGT [U/L]^a,b

0 – 2

1.10 ± 0.39

1.14 ± 0.43

1.33 ± 0.65

0.94 ± 0.05

AST [U/L]^a

0 – 55

21.7 ± 5.5

22.2 ± 8.6

22.0 ± 4.1

22.8 ± 6.8

ALT [U/L]

27 – 103

59.4 ± 10.1

54.6 ± 9.2

56.6 ± 9.4

55.3 ± 10.5

Creatine Kinase [U/L]

0 – 1213

1007 ± 1250

1479 ± 1901

975 ± 903

1763 ± 2175

Urea Nitrogen [mg/dL]

15 – 35

26.1 ± 5.4

25.3 ± 2.7

24.8 ± 4.0

25.2 ± 3.9

Creatinine [mg/dL]

0.5 - 1.3

0.83 ± 0.14

0.86 ± 0.13

0.85 ± 0.12

0.79 ± 0.12

Total Protein [g/dL]

5.4 - 6.7

6.02 ± 0.32

5.93 ± 0.28

6.03 ± 0.35

6.10 ± 0.34

Albumin [g/dL]

2.9 - 3.7

3.46 ± 0.17

3.31 ± 0.21

3.46 ± 0.17

3.44 ± 0.18

Globulin [g/dL]

2.1 - 3.3

2.57 ± 0.28

2.62 ± 0.23

2.57 ± 0.28

2.66 ± 0.29

Albumin/Globulin Ratio^a,b

0.9 - 1.5

1.36 ± 0.18

1.29 ± 0.14

1.36 ± 0.14

1.32 ± 0.16

Triglyceride [mg/dL]^a

12 – 64

38.7 ± 19.8

40.1 ± 27.2

32.4 ± 9.1

37.7 ± 14.7

Cholesterol [mg/dL]

88 – 148

105.4 ± 19.0

105.0 ± 18.1

103.9 ± 14.2

112.6 ± 23.7

Glucose [mg/dL]

55 - 159

86.0 ± 10.3

85.1 ± 7.1

84.1 ± 9.0

83.1 ± 6.2