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Table 3 Summary of post-treatment means (± SD) of hematology and coagulation variables (average of days 13 and 37)

From: Safety evaluation of the interchangeable use of robenacoxib in commercially-available tablets and solution for injection in cats

Variable

Reference range

Control

1X

2X

3X

Leukocytes [103/µL]

6.3 - 27.2

12.66 ± 3.76

13.95 ± 4.43

13.43 ± 3.10

14.76 ± 3.66

Erythrocytes [106/µL]

5.36 - 10.78

7.61 ± 0.58

7.24 ± 0.88

7.58 ± 0.82

7.73 ± 0.88

Hemoglobin [g/dL]

7.5 - 14.4

10.08 ± 0.89

9.96 ± 0.98

9.99 ± 1.06

10.13 ± 1.15

Hematocrit [%]

22.5 - 41.6

30.74 ± 2.73

30.66 ± 3.36

30.17 ± 3.65

30.90 ± 3.81

MCV [fL]

34.3 - 47.5

40.45 ± 2.59

42.49 ± 2.78

39.86 ± 3.11

40.03 ± 2.65

MCH [pg]

11.9 - 15.1

13.28 ± 0.96

13.82 ± 0.81

13.21 ± 0.99

13.11 ± 0.65

MCHC [g/dL]

30.4 - 38

32.84 ± 1.85

32.53 ± 0.55

33.14 ± 0.65

32.80 ± 1.57

Platelets [103/µL]

107 - 779

169.9 ± 134.8

253.7 ± 157.1

334.7 ± 155.9

301.4 ± 173.8

Neutrophils [103/µL]

0 - 12.65

5.13 ± 1.79

5.28 ± 1.75

5.73 ± 1.34

5.46 ± 1.04

Lymphocytes [103/µL]

2.18 - 13.48

5.73 ± 2.28

6.69 ± 2.61

6.16 ± 1.81

7.50 ± 2.64

Monocytes [103/µL]

0 - 0.81

0.24 ± 0.19

0.27 ± 0.22

0.28 ± 0.14

0.26 ± 0.15

Eosinophils [103/µL]a

0 - 1.31

0.96 ± 0.33

1.08 ± 0.40

0.94 ± 0.52

1.10 ± 0.40

Basophils [103/µL]

0 - 0.03

0.004 ± 0.008

0.006 ± 0.011

0.010 ± 0.011

0.006 ± 0.007

Other Cells [103/µL]

0 - 0.05

0.60 ± 0.90

0.62 ± 0.95

0.30 ± 0.71

0.44 ± 0.92

Absolute Aggregate Reticulocyte [103/µL]

12.9 - 106.6 

1.56 ± 4.14

4.02 ± 4.81

1.38 ± 4.14

1.45 ± 4.17

Absolute Punctate Reticulocyte [103/µL]

 

2012 ± 602

2277 ± 658

1915 ± 702

2129 ± 555

APTT [sec]

11.2 - 18.7

17.12 ± 3.74

23.35 ± 16.35

16.68 ± 2.52

16.83 ± 2.52

Prothrombin Time [sec]

8.7 - 11

10.73 ± 0.41

11.03 ± 0.62

10.77 ± 0.56

10.84 ± 0.46

Fibrinogen [mg/dL]

152 - 278

175.4 ± 26.1

180.8 ± 37.0

180.3 ± 22.2

172.5 ± 16.3

  1. *significant treatment effect  (p<0.1)
  2. asignificant treatment x sex effect (p<0.1)