Table 2 Overexpressed proteins commonly found in early-stage oral melanoma, late-stage oral melanoma and oral squamous cell carcinoma based on biological process involvement and protein score
Database | Protein name | Protein ID score | Peptides | Biological process | Subcellular distribution |
|---|---|---|---|---|---|
XP_005376885.1 | ATP synthase subunit s, mitochondrial isoform X1 | 4.77 | HQTMLFGK | ATP biosynthetic process | Mitochondria |
XP_004411845.1 | Carbonic anhydrase 12 isoform X1 | 33.40 | SLHAAAVLLLLCFK | Carbonate dehydratase activity | Integral component of membrane |
XP_015354861.1 | Cell division cycle-associated protein 2 | 17.63 | RSFCAPTLSSK | Cell cyclecell division | Nucleus |
XP_004625867.1 | dihydroorotate dehydrogenase (quinone), mitochondrial | 17.17 | IPIIGVGGVSSGQDAMDK | ‘de novo’ UMP biosynthetic process | Mitochondrion inner membrane |
XP_014948096.1 | Hermansky–Pudlak syndrome 3 protein isoform X1 | 9.93 | ACPPISMDVCALR | Organelle organization,pigmentation | Cytosol |
XP_004644982.1 | KN motif and ankyrin repeat domain-containing protein 3 | 14.22 | FALNQNLPDLGGSR | Negative regulation of actin filament polymerization | Cytoplasm |
XP_008158631.1 | Leucocyte immunoglobulin-like receptor subfamily A member 6 | 3.43 | EPAEVEELK | Adaptive immune response | Membrane |
XP_003787787.1 | Negative elongation factor C/D | 7.47 | SNFIMMN | Transcription by RNA polymerase II | Nucleus |
XP_011285357.1 | Neurexin-2-β | 13.66 | VVVVLGGQGSSG | Neuron cell–cell adhesion signal transduction | Membrane |
XP_005629058.1 | Origin recognition complex subunit 1 isoform X1 | 6.66 | SRPTPSHPATPRAK | DNA replication,mitotic cell cycle | Nucleus |
XP_006896914.1 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1 | 18.32 | ARVSQM | Gluconeogenesis | Cytosol |
XP_004620060.1 | Phospholipase B1, membrane-associated-like | 11.55 | RMENNSGINFNEDWK | Phospholipase activity | Integral component of membrane |
XP_012626009.1 | Progesterone receptor isoform X2 | 17.75 | VLLLLNTTR | DNA-binding transcription factor activity | Nucleus |
XP_008151988.1 | Secernin-2 | 13.13 | QGGITAEAMMDILRDK | Exocytosis | Extracellular exosome |
XP_007489730.1 | Sodium/iodide cotransporter | 6.99 | DSKEYPQEVK | Cellular response to cAMP | Membrane |
XP_016811442.1 | T-box transcription factor TBX18 isoform X2 | 12.54 | MYSGELGPI | DNA-binding transcription factor activity | Nucleus |
XP_004045865.1 | Uncharacterized protein LOC101132572 | 12.64 | RFTLSLDAPAPTQGVCK | Unknown | Unknown |
XP_006190947.1 | Zinc finger protein ZIC 3 | 8.6 | THTGKGEGGR | Cell differentiation | Nucleus |
XP_011744397.1 | 28S ribosomal protein S14, mitochondrial | 16.97 | KNTXLPK | Mitochondrial translational elongation and translation | Mitochondria |
XP_007505382.1 | 3-hydroxyisobutyrate dehydrogenase, mitochondrial isoform X1 | 8.97 | SMASKTPVGFVGLGNMGNPMAK | 3-hydroxyisobutyrate dehydrogenase activity | Mitochondria |
XP_004448347.1 | α-ketoglutarate-dependent dioxygenase alkB homolog 4 isoform X1 | 7.08 | LVSLNLLSSTVLSMSR | Demethylation | Mitochondria |
XP_005065718.1 | Ankyrin repeat domain-containing protein 34B | 20.75 | QKALMTTNGPK | Unknown | Nucleus |
NP_036833.1 | β1 adrenergic receptor | 13.02 | QGFSSESK | Adenylate cyclase-activating adrenergic receptor signalling pathway | Endosome,plasma membrane |
ELK12127.1 | Cytochrome b-c1 complex subunit 2, mitochondrial | 11.51 | DNMAYTGEGLR | Aerobic respiration | Mitochondria |
XP_006883886.1 | E3 SUMO-protein ligase RanBP2 | 11.07 | LSQSGHMLINLSRGK | centrosome localization | Nucleus |
BAD96349.1 | Heme oxygenase (decyclizing) 2 variant | 11.2 | KSSGALEK | Heme oxygenase (decyclizing) 2 variant | Endoplasmic reticulum |
OBS70980.1 | Pyrroline-5-carboxylate reductase | 9.86 | LTAFXPAPK | L-proline biosynthetic process | Mitochondria |
XP_015976454.1 | Laminin subunit α1 | 15.83 | YXNGTWYK | Cell adhesion | Extracellular region or secreted |
KFO28259.1 | Mitochondrial import receptor subunit TOM20 like protein | 10.02 | LFSVQMPLAKLPTTGQR | Protein import into mitochondrial matrix | Mitochondria |
EAW72809.1 | Signal sequence receptor, delta (translocon-associated protein delta), isoform CRA_c | 3.09 | APTQAPMR | Regulate the retention of ER resident proteins | Endoplasmic reticulum |
XP_006865897.1 | Tyrosine-protein phosphatase non-receptor type 5 | 21.9 | AEGLRGSHR | Cellular response to cytokine stimulus | Endoplasmic reticulum |