Table 1 Overexpressed proteins uniquely found in normal controls and periodontitis, benign oral tumors, early-stage oral melanoma, late-stage oral melanoma and oral squamous cell carcinoma based on biological process involvement and protein score

 XP_016007048.1

Semaphorin-4B isoform X1

QLVASYCPK

1. Negative chemotaxis

2. Semaphorin–plexin signalling pathway

1. Extracellular space

2. Integral component of plasma membrane

 XP_011988340.1

Visual system homoeobox 1 isoform X2

FPGRPLPSAARQK

1. Multicellular organism development

2. Regulation of transcription

1. Nucleus

2. Cytoskeleton

 XP_013973434.1

CDK5 regulatory subunit-associated protein 2 isoform X1

FTNQGKR

Microtubule organizing center

 XP_002689199.3

Olfactory receptor 2 M5

MCWQVAAMSWAGGAR

Olfaction

Plasma membrane

 XP_008048855.1

Potassium voltage-gated channel subfamily Q member 1

LNIEDFR

1. Potassium ion export across plasma membrane

2. Cellular response to cAMP

1. Endoplasmic reticulum

2. Endosome

3. Plasma membrane

 XP_007125871.1

GLIPR1-like protein 1

AHNEAR

Single fertilization

Plasma membrane

 EHB15707.1

Transient receptor potential cation channel subfamily M member 5

TVAPKSLLFR

Ion transmembrane transport

Plasma membrane

 KFO21119.1

Germ cell-less protein-like 1

KAVAAR

Cell differentiation

Nucleus

 XP_004629194.1

Poly [ADP-ribose] polymerase 12

KLGMSSELVHR

Protein auto-ADP-ribosylation

Nucleus

 XP_015289690.1

Lamin tail domain-containing protein 2

GLLPPMSSGK

Cell population proliferation

1. Cytoskeleton

2. Nucleus

 XP_012868232.1

Telomeric repeat-binding factor 2-interacting protein 1

AEPDPEAAESVEPQTK

1. Negative regulation of DNA recombination at telomere

2. Positive regulation of NF-κB transcription factor activity

Nucleus

 XP_012373519.1

Myb-related protein B

MLPGRYVPGGGVGAR

1. Mitotic cell cycle

2. Regulation of cell cycle

Nucleus

 XP_012865682.1

Erythrocyte membrane protein band 4.2

QWSAVVEDR

1. Cell morphogenesis

2. Hemoglobin metabolic process

Cytoskeleton

1. Cytoplasm

2. Membrane

 XP_005371197.1

Long-chain-fatty-acid–CoA ligase ACSBG2

APGTGFLTEMLR

cell differentiation

 XP_011760132.1

Putative protein SSX6

GGNMPGPTGCVR

Regulation of transcription, DNA-templated

Nucleus

 XP_004326275.1

Bromodomain testis-specific protein-like

DNAKPMNYDEKR

Chromatin remodelling

Nucleus

 XP_006868797.1

Zinc finger protein GLI2-like

GGSLENSSIPDLSR

Nucleic acid binding

Nucleus

 EPQ15807.1

Transformation/transcription domain-associated protein

AMAILTPAVPAR

1. DNA repair

2. Histone deubiquitination

1. Golgi apparatus

2. Nucleus

 XP_009240233.1

Glutathione S-transferase-like

ARISHILTINK

Glutathione transferase activity

Cytoplasm

 XP_011282224.1

Protein FAM186A

SVEQSFLELLIEEDR

No data

1. Nucleus

2. Cytoplasm

 XP_004412391.1

Deleted in lung and oesophageal cancer protein 1

AGPPKNK

Negative regulation of cell population proliferation

Cytoplasm

 XP_007944568.1

Ankyrin repeat domain-containing protein 26-like

ADIKENMVIDMQANCMILXK

Protein interaction

Cytoplasm

 XP_012392091.1

Cytohesin-4 isoform X2

YPGELSSGEAEELQR

Regulation of ARF protein signal transduction

Nucleus

 XP_007532207.2

Probable C-mannosyltransferase DPY19L4

KPKSSGNK

Protein C-linked glycosylation via 2′-alpha-mannosyl-L-tryptophan

Membrane

 EHB17858.1

Dynein heavy chain 11, axonemal

ATSEMR

Determination of left/right symmetry

Cytoskeleton

 XP_004275614.1

Fanconi anaemia-associated protein of 100 kDa

XGMDDR

Interstrand cross-link repair

Nucleus

 OBS77059.1

Protein A6R68_16468

DQVSDDVSVQSSGPNCQR

Regulation of transcription by RNA polymerase II

Nucleus