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Table 1  Histological and molecular findings of herpesvirus infection in 14 stranded dolphins

From: Alpha- and gammaherpesviruses in stranded striped dolphins (Stenella coeruleoalba) from Spain: first molecular detection of gammaherpesvirus infection in central nervous system of odontocetes

ID Sex Main histopathological findings Tissues tested for HV
6 M Systemic congestion, severe; Lymphoplasmacytic and suppurative balanitis, mild; Granulomatous and eosinophilic lymphadenitis, mild; Lymphoplasmacytic cholangitis, mild Cerebellum, spinal cord (A, MN699008), lung, liver, spleen, kidney, skin, pharyngeal tonsils, tracheobronchial lymph node, pre-scapular lymph node, mesenteric lymph node, penis (G, MN698989)
7 M Systemic congestion, severe; Meningeal hemorrhage and congestion; Lymphoplasmacytic encephalitis, minimal; Lymphoplasmacytic and suppurative balanitis, mild; Lymphoplasmacytic cholangitis, moderate; Polysaccharide myocyte inclusions Cerebrum (A, MN699009), cerebellum, spinal cord, lung, liver, spleen, kidney, skin, pharyngeal tonsils, tracheobronchial lymph node, pre-scapular lymph node, mesenteric lymph node, penis (G, MN698990)
8 Fa Systemic congestion, severe; Lymphoplasmacytic placentitis, minimal; Granulomatous cholangiohepatitis with intralesional trematodes, moderate; Granulomatous and eosinophilic lymphadenitis, moderate; Poxvirus-like dermatitis, mild Cerebrum, cerebellum, spinal cord, lung, liver, spleen, kidney, skin, pharyngeal tonsils, tracheobronchial lymph node (MT770752), pre-scapular lymph node, mesenteric lymph node.
9 F Lymphoplasmacytic encephalitis, mild; Systemic congestion and microhemorrhages, severe; suppurative endometritis, mild; Granulomatous and eosinophilic lymphadentitis, moderate Cerebrum, cerebellum, spinal cord, lung, liver, spleen, kidney, skin, pharyngeal tonsils, tracheobronchial lymph node, pre-scapular lymph node, mesenteric lymph node
10 M Systemic congestion, severe; Necrosuppurative hepatitis, moderate; Lymphoplasmacytic encephalitis, mild; Granulomatous and eosinophilic lymphadenitis, bronchopneumonia, colitis and gastritis, moderate; Polysaccharide myocyte inclusions Cerebrum, cerebellum (G, MN698991), spinal cord (G, MN698992), lung (MT770744), liver, spleen, kidney, skin (MT770743), pharyngeal tonsils (MT770742), tracheobronchial lymph node (MT770741), pre-scapular lymph node, mesenteric lymph node, penis (G, MN698993)
11 M Systemic congestion, severe; Lymphoplasmacytic encephalitis, mild; lymphoplasmacytic hepatitis, mild; Granulomatous and eosinophilic lymphadenitis, bronchopneumonia, colitis, mild; Myonecrosis, mild Cerebrum, cerebellum, spinal cord (A, MN699007), lung, liver, spleen, kidney, skin, pharyngeal tonsils (MT770748), tracheobronchial lymph node, pre-scapular lymph node, mesenteric lymph node, penis (G, MN698994)
12 M Systemic congestion, severe; Lymphoplasmacytic encephalitis, mild; lymphoplasmacytic hepatitis, mild; Granulomatous and eosinophilic lymphadenitis, bronchopneumonia Cerebrum, cerebellum, spinal cord, lung, liver, spleen, kidney, skin (MT770749), pharyngeal tonsils (MT770751), tracheobronchial lymph node (MT770750), pre-scapular lymph node, mesenteric lymph node, penis
13 M Necrosuppurative hepatitis, moderate; Lymphoplasmacytic encephalitis, mild; Granulomatous and eosinophilic lymphadenitis as well as systemic congestion, severe Cerebrum (G, MN698995), cerebellum (G, MN698996), spinal cord (G, MN698997), lung, liver, spleen, kidney, skin, pharyngeal tonsils (MT770746), tracheobronchial lymph node, pre-scapular lymph node, mesenteric lymph node (MT770747), penis (G, MN698998)
14 M Systemic congestion, severe; Lymphoplasmacytic and histiocytic bronchopneumonia, moderate; Lymphoplasmacytic encephalitis, mild; Granulomatous and eosinophilic lymphadenitis, gastritis and duodenitis with intralesional trematodes, moderate Cerebrum, cerebellum, spinal cord, lung, liver, spleen, kidney, skin (MT770740), pharyngeal tonsils, tracheobronchial lymph node, pre-scapular lymph node, mesenteric lymph node, penis (G, MN698999)
15 F Systemic congestion, severe; Acute myonecrosis, severe; Granulomatous and eosinophilic lymphadenitis, pneumonia and colitis, mild; Lymphoplasmacytic encephalitis, mild; Lymphoplasmacytic cholangiohepatitis, mild Cerebrum, cerebellum, spinal cord, lung, liver, spleen, kidney, skin (MT770745), pharyngeal tonsils, tracheobronchial lymph node, pre-scapular lymph node, mesenteric lymph node
16 Fa Systemic congestion, severe; Pulmonary haemorrhage and atelectasis, severe; Granulomatous and eosinophilic lymphadenitis and gastritis Cerebrum, cerebellum, spinal cord, lung, liver, spleen, kidney, skin, pharyngeal tonsils, tracheobronchial lymph node, pre-scapular lymph node, mesenteric lymph node
17 M Systemic congestion, severe; Granulomatous and eosinophilic lymphadenitis, gastritis, colitis; Penile papilloma; Lymphoplasmacytic balanitis, mild Cerebrum (G, MN699000), cerebellum (G, MN699001), spinal cord (G, MN699002), lung, liver, spleen, kidney, skin, pharyngeal tonsils, tracheobronchial lymph node, pre-scapular lymph node, mesenteric lymph node, penis (G, MN699003)
18 F Systemic congestion, severe; Bacterial sepsis; Necrosuppurative hepatitis, moderate; Suppurative and haemorrhagic pneumonia, moderate; Acute myonecrosis, mild; Granulomatous and eosinophilic lymphadenitis and gastritis, mild Cerebrum, cerebellum, spinal cord, lung, liver, spleen, kidney, skin, pharyngeal tonsils, tracheobronchial lymph node, pre-scapular lymph node, mesenteric lymph node,
19 M Systemic congestion, severe; Lymphoplasmacytic and histiocytic meningitis, mild; Granulomatous and eosinophilic lymphadentitis and colitis Cerebrum (G, MN699004), cerebellum, spinal cord (G, MN699005), lung, liver, spleen, kidney, skin, pharyngeal tonsils, tracheobronchial lymph node, pre-scapular lymph node, mesenteric lymph node, penis (G, MN699006)
  1. Samples positive by nested PCR are underlined. Accession numbers of herpesvirus DNA sequences are indicated in parentheses
  2. Abbreviations: A Alphaherpesvirus, F female, Fapregnant female, G Gammaherpesvirus, M male