Skip to main content

Table 1 The differentially expressed proteins from hypothalamus in pigs under HS

From: Proteomic study of hypothalamus in pigs exposed to heat stress

Protein name Accession number Peptides Ratio (Heat stress/Control) Functions
Down-regulated in Hypothalamus
 Heat shock 70 kDa protein 12A gi|350,593,095 7 0.439 ATP binding
 Similar to V-type proton ATPase subunit E 1 isoform 2 gi|350,584,473 6 0.513 hydrogen-exporting ATPase activity, phosphorylative mechanism
 HPCA gi|115,394,790 7 0.151 actin binding and calcium ion binding
 Heat shock 90kD protein 1, beta gi|346,986,428 15 0.666 GTP, CTP binding and UTP binding, chaperones
 Similar to protein kinase C and casein kinase substrate in neurons protein 1-like gi|335,292,069 7 0.179 cytoskeletal protein binding
 Tubulin polymerization promoting protein p25 alpha gi|170,178,280 7 0.225 microtubule binding and calcium ion binding
 Similar to annexin A6-like gi|350,594,505 10 0.611 calcium ion binding
 Similar to tubulin alpha-4A chain gi|335,303,414 18 0.161 protein binding and GTP binding
 Na+/K+ transporting alpha 3 polypeptide gi|283,443,672 25 0.282 metal ion binding and sodium: potassium-exchanging ATPase activity
 Similar to pyruvate kinase isozymes M1/M2 isoform 1 gi|194,038,728 17 0.4 pyruvate kinase activity
 Similar to guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2-like isoform 2 gi|311,251,041 5 0.474 signal transducer activity
 Similar to erythrocyte membrane protein band 4.1-like 1 isoform 1 gi|335,304,751 9 0.601 actin binding and structural molecule activity
 Tubulin beta-2B chain gi|343,478,189 16 0.154 structural molecule activity
 Clathrin heavy chain gi|224,492,556 38 0.362 ankyrin binding and structural molecule activity
 Similar to contactin-1-like isoform 2 gi|350,584,500 12 0.343 glycoprotein binding and carbohydrate binding
hexokinase 1 gi|342,187,282 15 0.637 hexokinase activity
 Similar to synaptic vesicle glycoprotein 2A gi|194,036,298 6 0.325 Receptor and transmembrane transporter activity
 Galectin-1 gi|47,716,872 7 0.431 signal transducer activity and laminin binding
 Synapsin Ib gi|212,525,788 13 0.205 ATP binding and actin binding
 Similar to tubulin alpha-1D chain gi|194,043,861 17 0.121 GTP binding and protein heterodimerization activity
Up-regulated protein in hypothalamus
 Annexin A2 gi|52,631,987 14 2.322 phosphatidylinositol-4,5-bisphosphate binding
 Hsp27 gi|55,668,280 6 2.771 protein kinase C binding and protein kinase C inhibitor activity
 Similar to annexin A11 gi|194,042,189 6 2.757 serine-type endopeptidase inhibitor activity
 Similar to prohibitin gi|3a50590415 6 1.519 sequence-specific DNA binding RNA polymerase II transcription factor activity
 Similar to glyoxalase domain-containing protein 4-like gi|335,298,275 7 1.616 Amino acid transport and metabolism
 Stress-70 protein, mitochondrial gi|311,250,237 16 2.105 ATP binding and unfolded protein binding, testosterone 17-beta-dehydrogenase (NADP+)
 Similar to protein disulfide-isomerase A4-like gi|311,264,773 11 1.889 electron carrier activity and protein binding
 long-chain 3-ketoacyl-CoA thiolase gi|6,165,556 7 3.162 NAD binding and long-chain- enoyl-CoA hydratase activity
 Similar to ezrin gi|350,578,005 9 4.869 cell adhesion molecule binding and actin filament binding
 Gastrin-binding protein gi|433,066 9 2.614 acetyl-CoA C-acetyltransferase activity
 Ppk 98; a protein kinase gi|431,944 20 1.783 virion and calcium ion binding
 78 kDa glucose-regulated protein gi|350,579,657 22 1.634 chaperone binding and unfolded protein binding
 Heat shock 10kD protein gi|30,525,868 7 10.249 chaperone binding
 Similar to caldesmon gi|311,275,365 5 2.353 Calmodulin, actin and myosin binding
 Similar to annexin A5 gi|335,293,906 12 2.117 calcium ion binding; binding, bridging
 Similar to annexin A11 gi|194,042,189 6 2.757 serine-type endopeptidase inhibitor activity
 Similar to selenium-binding protein 1 gi|194,036,227 20 2.677 selenium and protein binding
 Non-selenium glutathione phospholipid hydroperoxide peroxidase (PHGPx) gi|6,689,393 7 2.148 glutathione peroxidase activity
 Similar to serpin A3–8 gi|350,587,171 10 4.428 serine-type endopeptidase inhibitor activity
 Glucosidase 2 subunit beta precursor gi|347,446,687 6 1.733 phosphatidylinositol binding