From: Proteomic study of hypothalamus in pigs exposed to heat stress
Protein name | Accession number | Peptides | Ratio (Heat stress/Control) | Functions |
---|---|---|---|---|
Down-regulated in Hypothalamus | ||||
Heat shock 70 kDa protein 12A | gi|350,593,095 | 7 | 0.439 | ATP binding |
Similar to V-type proton ATPase subunit E 1 isoform 2 | gi|350,584,473 | 6 | 0.513 | hydrogen-exporting ATPase activity, phosphorylative mechanism |
HPCA | gi|115,394,790 | 7 | 0.151 | actin binding and calcium ion binding |
Heat shock 90kD protein 1, beta | gi|346,986,428 | 15 | 0.666 | GTP, CTP binding and UTP binding, chaperones |
Similar to protein kinase C and casein kinase substrate in neurons protein 1-like | gi|335,292,069 | 7 | 0.179 | cytoskeletal protein binding |
Tubulin polymerization promoting protein p25 alpha | gi|170,178,280 | 7 | 0.225 | microtubule binding and calcium ion binding |
Similar to annexin A6-like | gi|350,594,505 | 10 | 0.611 | calcium ion binding |
Similar to tubulin alpha-4A chain | gi|335,303,414 | 18 | 0.161 | protein binding and GTP binding |
Na+/K+ transporting alpha 3 polypeptide | gi|283,443,672 | 25 | 0.282 | metal ion binding and sodium: potassium-exchanging ATPase activity |
Similar to pyruvate kinase isozymes M1/M2 isoform 1 | gi|194,038,728 | 17 | 0.4 | pyruvate kinase activity |
Similar to guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2-like isoform 2 | gi|311,251,041 | 5 | 0.474 | signal transducer activity |
Similar to erythrocyte membrane protein band 4.1-like 1 isoform 1 | gi|335,304,751 | 9 | 0.601 | actin binding and structural molecule activity |
Tubulin beta-2B chain | gi|343,478,189 | 16 | 0.154 | structural molecule activity |
Clathrin heavy chain | gi|224,492,556 | 38 | 0.362 | ankyrin binding and structural molecule activity |
Similar to contactin-1-like isoform 2 | gi|350,584,500 | 12 | 0.343 | glycoprotein binding and carbohydrate binding |
hexokinase 1 | gi|342,187,282 | 15 | 0.637 | hexokinase activity |
Similar to synaptic vesicle glycoprotein 2A | gi|194,036,298 | 6 | 0.325 | Receptor and transmembrane transporter activity |
Galectin-1 | gi|47,716,872 | 7 | 0.431 | signal transducer activity and laminin binding |
Synapsin Ib | gi|212,525,788 | 13 | 0.205 | ATP binding and actin binding |
Similar to tubulin alpha-1D chain | gi|194,043,861 | 17 | 0.121 | GTP binding and protein heterodimerization activity |
Up-regulated protein in hypothalamus | ||||
Annexin A2 | gi|52,631,987 | 14 | 2.322 | phosphatidylinositol-4,5-bisphosphate binding |
Hsp27 | gi|55,668,280 | 6 | 2.771 | protein kinase C binding and protein kinase C inhibitor activity |
Similar to annexin A11 | gi|194,042,189 | 6 | 2.757 | serine-type endopeptidase inhibitor activity |
Similar to prohibitin | gi|3a50590415 | 6 | 1.519 | sequence-specific DNA binding RNA polymerase II transcription factor activity |
Similar to glyoxalase domain-containing protein 4-like | gi|335,298,275 | 7 | 1.616 | Amino acid transport and metabolism |
Stress-70 protein, mitochondrial | gi|311,250,237 | 16 | 2.105 | ATP binding and unfolded protein binding, testosterone 17-beta-dehydrogenase (NADP+) |
Similar to protein disulfide-isomerase A4-like | gi|311,264,773 | 11 | 1.889 | electron carrier activity and protein binding |
long-chain 3-ketoacyl-CoA thiolase | gi|6,165,556 | 7 | 3.162 | NAD binding and long-chain- enoyl-CoA hydratase activity |
Similar to ezrin | gi|350,578,005 | 9 | 4.869 | cell adhesion molecule binding and actin filament binding |
Gastrin-binding protein | gi|433,066 | 9 | 2.614 | acetyl-CoA C-acetyltransferase activity |
Ppk 98; a protein kinase | gi|431,944 | 20 | 1.783 | virion and calcium ion binding |
78 kDa glucose-regulated protein | gi|350,579,657 | 22 | 1.634 | chaperone binding and unfolded protein binding |
Heat shock 10kD protein | gi|30,525,868 | 7 | 10.249 | chaperone binding |
Similar to caldesmon | gi|311,275,365 | 5 | 2.353 | Calmodulin, actin and myosin binding |
Similar to annexin A5 | gi|335,293,906 | 12 | 2.117 | calcium ion binding; binding, bridging |
Similar to annexin A11 | gi|194,042,189 | 6 | 2.757 | serine-type endopeptidase inhibitor activity |
Similar to selenium-binding protein 1 | gi|194,036,227 | 20 | 2.677 | selenium and protein binding |
Non-selenium glutathione phospholipid hydroperoxide peroxidase (PHGPx) | gi|6,689,393 | 7 | 2.148 | glutathione peroxidase activity |
Similar to serpin A3–8 | gi|350,587,171 | 10 | 4.428 | serine-type endopeptidase inhibitor activity |
Glucosidase 2 subunit beta precursor | gi|347,446,687 | 6 | 1.733 | phosphatidylinositol binding |