Table 3 Putative FQ resistance mutations and mutation rate
NO of isolates and DANO MIC (μg/mL) | Topoisomerases and gyrase mutations | Efflux-related mutations | |||
|---|---|---|---|---|---|
gyrA | parC | parE | marR | acrR | |
13 (128); 2 (64); | S83L, D87N | None | None | None | None |
2 (128); 1 (64) | S83L, D87N | S80I | None | None | None |
5 (128); 3 (64) | S83L, D87N | S80I | None | G103S | None |
2 (128); 1 (32) | S83L, D87N | None | None | G103S | None |
2 (128); 1 (32); 2 (8) | None | S80I | None | G103S | None |
1 (128); 1 (64) | S83L, D87N | S80I | I355T,L416F | None | None |
1 (128) | None | S80I | None | G103S | V29G |
1 (64) | S83L, D87Y | S80I | None | G103S | None |
1 (64) | S83L, D87H | None | None | G103S | None |
1 (64) | S83L, D87N | None | None | D67N,G103S | None |
1 (32) | S83L, D87Y | S80I | None | None | None |
2 (32) | S83L | None | None | G103S | None |
1 (32) | S83L | None | None | None | None |
1 (32) | S83L, D87G | None | None | None | None |
1 (16) | None | S80I, E84K | None | None | None |
1 (16) | None | E84K | None | None | None |
1 (1) | None | S80I | None | None | None |
1 (32)1 (4); 1 (1) | None | None | None | G103S | None |
mutation rate | 52.70% | 28.38% | 2.70% | 35.14% | 1.35% |